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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-10-31
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pubmed:abstractText |
The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazolone,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidines,
http://linkedlifedata.com/resource/pubmed/chemical/SR 140333,
http://linkedlifedata.com/resource/pubmed/chemical/TRPV Cation Channels,
http://linkedlifedata.com/resource/pubmed/chemical/TRPV1 receptor,
http://linkedlifedata.com/resource/pubmed/chemical/resiniferatoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
86-96
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:16188326-Adjuvants, Immunologic,
pubmed-meshheading:16188326-Animals,
pubmed-meshheading:16188326-Calcitonin Gene-Related Peptide,
pubmed-meshheading:16188326-Cytokines,
pubmed-meshheading:16188326-Dermatitis, Allergic Contact,
pubmed-meshheading:16188326-Disease Models, Animal,
pubmed-meshheading:16188326-Diterpenes,
pubmed-meshheading:16188326-Ear Diseases,
pubmed-meshheading:16188326-Mice,
pubmed-meshheading:16188326-Mice, Inbred BALB C,
pubmed-meshheading:16188326-Mice, Inbred C57BL,
pubmed-meshheading:16188326-Mice, Knockout,
pubmed-meshheading:16188326-Neutrophils,
pubmed-meshheading:16188326-Oxazolone,
pubmed-meshheading:16188326-Piperidines,
pubmed-meshheading:16188326-Quinuclidines,
pubmed-meshheading:16188326-TRPV Cation Channels,
pubmed-meshheading:16188326-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.
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pubmed:affiliation |
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, H-7624 Pécs, Szigeti. u. 12, Hungary.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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