Linked Life Data

16188207

Source:http://linkedlifedata.com/resource/pubmed/id/16188207

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-9-28
pubmed:abstractText
Dietary intake of omega-3 fatty acids has been positively correlated with cardiovascular and neuropsychiatric health in several studies. The high seafood intake by the Japanese and Greenland Inuit has resulted in low ratios of the omega-6 fatty acid arachidonic acid (AA, 20:4n-6) to eicosapentaenoic acid (EPA, 20:5n-3), with the Japanese showing AA:EPA ratios of approximately 1.7 and the Greenland Eskimos showing ratios of approximately 0.14. It was the objective of this study to determine the effect of supplementation with high doses (60 g) of flax and fish oils on the blood phospholipid (PL) fatty acid status, and AA/EPA ratio of individuals with Attention Deficit Hyperactivity Disorder (ADHD), commonly associated with decreased blood omega-3 fatty acid levels. Thirty adults with ADHD were randomized to 12 weeks of supplementation with olive oil (< 1% omega-3 fatty acids), flax oil (source of alpha-linolenic acid; 18:3n-3; alpha-LNA) or fish oil (source of EPA and docosahexaenoic acid; 22:6n-3; DHA). Serum PL fatty acid levels were determined at baseline and at 12 weeks. Flax oil supplementation resulted in an increase in alpha-LNA and a slight decrease in the ratio of AA/EPA, while fish oil supplementation resulted in increases in EPA, DHA and total omega-3 fatty acids and a decrease in the AA/EPA ratio to values seen in the Japanese population. These data suggest that in order to increase levels of EPA and DHA in adults with ADHD, and decrease the AA/EPA ratio to levels seen in high fish consuming populations, high dose fish oil may be preferable to high dose flax oil. Future study is warranted to determine whether correction of low levels of long-chain omega-3 fatty acids is of therapeutic benefit in this population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0926-5287
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
549-58
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16188207-Adolescent, pubmed-meshheading:16188207-Adult, pubmed-meshheading:16188207-Aged, pubmed-meshheading:16188207-Analysis of Variance, pubmed-meshheading:16188207-Arachidonic Acid, pubmed-meshheading:16188207-Attention Deficit Disorder with Hyperactivity, pubmed-meshheading:16188207-Dietary Supplements, pubmed-meshheading:16188207-Docosahexaenoic Acids, pubmed-meshheading:16188207-Dose-Response Relationship, Drug, pubmed-meshheading:16188207-Eicosapentaenoic Acid, pubmed-meshheading:16188207-Fatty Acids, Omega-3, pubmed-meshheading:16188207-Female, pubmed-meshheading:16188207-Fish Oils, pubmed-meshheading:16188207-Humans, pubmed-meshheading:16188207-Linseed Oil, pubmed-meshheading:16188207-Male, pubmed-meshheading:16188207-Middle Aged, pubmed-meshheading:16188207-Phospholipids, pubmed-meshheading:16188207-Plant Oils
pubmed:articleTitle
Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder.
pubmed:affiliation
Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 5B6, Canada.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't