Source:http://linkedlifedata.com/resource/pubmed/id/16187834
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2005-9-28
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| pubmed:abstractText |
Lactating female mice fiercely defend offspring while exhibiting decreased fear and anxiety. Recent work (J. S. Lonstein & S. C. Gammie, 2002) found that intracerebroventricular (icv) injections of corticotropin releasing factor (CRF), a putative anxiogenic peptide, inhibit maternal defense behavior. This study examines effects of CRF-related peptides, urocortin (Ucn) 1 and Ucn 3, on maternal aggression in mice. Intracerebroventricular injections of both Ucn 1 (0.2 microg) and Ucn 3 (0.5 microg) reduced aggression but not pup retrieval. c-Fos levels were elevated by intracerebroventricular injections of Ucn 1 (0.2 microg) and Ucn 3 (0.5 microg) in 2 and 6 brain regions, respectively; however, both triggered increases in bed nucleus of the stria terminalis dorsal (BNSTd) and lateral septum (LS). These findings suggest that CRF-related peptides similarly modulate maternal aggression and that BNSTd/LS may be critical sites for negative regulation of maternal aggression.
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| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
0735-7044
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| pubmed:author | |
| pubmed:copyrightInfo |
(c) 2005 APA
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| pubmed:issnType |
Print
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| pubmed:volume |
119
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1061-71
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| pubmed:dateRevised |
2011-10-14
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| pubmed:meshHeading |
pubmed-meshheading:16187834-Aggression,
pubmed-meshheading:16187834-Analysis of Variance,
pubmed-meshheading:16187834-Animals,
pubmed-meshheading:16187834-Behavior, Animal,
pubmed-meshheading:16187834-Cell Count,
pubmed-meshheading:16187834-Corticotropin-Releasing Hormone,
pubmed-meshheading:16187834-Dose-Response Relationship, Drug,
pubmed-meshheading:16187834-Female,
pubmed-meshheading:16187834-Gene Expression Regulation,
pubmed-meshheading:16187834-Immunohistochemistry,
pubmed-meshheading:16187834-Injections, Intraventricular,
pubmed-meshheading:16187834-Maternal Behavior,
pubmed-meshheading:16187834-Mice,
pubmed-meshheading:16187834-Mice, Inbred ICR,
pubmed-meshheading:16187834-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:16187834-Septal Nuclei,
pubmed-meshheading:16187834-Urocortins
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| pubmed:year |
2005
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| pubmed:articleTitle |
Urocortin 1 and 3 impair maternal defense behavior in mice.
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| pubmed:affiliation |
Department of Zoology, University of Wisconsin-Madison, Madison, WI 53706, USA. kldanna@wisc.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
|