Linked Life Data

16186755

Source:http://linkedlifedata.com/resource/pubmed/id/16186755

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-9-27
pubmed:abstractText
Solutions of EDTA and citric acid have been used as canal irrigants. These substances must be compatible with apical periodontal tissue. The aim of this study was to evaluate comparatively the cytotoxicity of a 17% EDTA solution and that of three solutions with different concentrations of citric acid (10, 15, and 25%) on cultured fibroblasts. The solutions were diluted to 0.1% and 0.5% in culture medium and then applied to NIH 3T3 cells. After 0, 6, 12, and 24 h (short-term assay; viability) and 1, 3, 5, and 7 days (long-term assay; survival), the cells were counted. The data were compared by ANOVA. In the short-term experiments, all solutions presented a percentage of cell viability similar to that of control cells, except for the 17% EDTA solution diluted to 0.5%. After the long-term assay, all groups presented a continuous and progressive cell growth except for the 17% EDTA solution and for the 25% citric acid solution at a 0.5% dilution. The citric acid solution did not impair cell growth and viability, proving to be noncytotoxic in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0099-2399
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
746-8
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
In vitro evaluation of the cytotoxic effects of acid solutions used as canal irrigants.
pubmed:affiliation
Department of Endodontics, School of Dentistry, University of São Paulo, Cidade Universitária, São Paulo, SP, Brazil.
pubmed:publicationType
Journal Article