Linked Life Data

1618590

Source:http://linkedlifedata.com/resource/pubmed/id/1618590

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-8-3
pubmed:abstractText
We have investigated the influence of nutrition on immune function in animals and man over the past two decades. The profound impairment of immune function that had not been observed in children in developing countries could not consistently be reproduced in the laboratory setting; paradoxically, moderate nutritional restriction could even enhance T-cell-based cell-mediated immune responses in experimental animals. Studies of the crucial role of the element zinc in maintenance of vigorous cellular immunity provided at least a partial explanation of this paradox. Zinc, shown to be absolutely crucial for development and expression of both T- and B-cell functions, was commonly deficient as were other micronutrients under many conditions of protein-calorie malnutrition. Indeed, administration of adequate zinc alone could correct some of the T-cell-mediated immune functions in children with protein-calorie malnutrition. In later investigations we found that as long as all essential nutrients were supplied in adequate amounts, 40% chronic energy (calorie) restriction will regularly extend lifespan and maintain vigorous immunologic function while preventing numerous cancers and immunologically based diseases of aging, such as profound and destructive autoimmune diseases in genetically short-lived mice strains, as it was known to do for moderately long-lived rats and long-lived strains of mice. Such undernutrition without malnutrition appears to influence a wide range of critical metabolic and physiologic processes in both short-lived and long-lived animals. One of the most challenging of these influences was a down-regulation of cellular proliferation and cell turnover in each of the rapidly replicating tissues studied.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0192-0561
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
361-6
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Nutrition and cellular immunity.
pubmed:affiliation
Department of Pediatrics, All Children's Hospital, University of South Florida, St. Petersburg.
pubmed:publicationType
Journal Article, Review