Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-9-27
pubmed:abstractText
A dysregulated inflammatory response in the central nervous system (CNS) lies at the heart of many neuropathological conditions such as multiple sclerosis and Alzheimer's disease. A key component of these inflammatory conditions is the accumulation of leukocytes in the CNS. The infiltration of leukocytes into the brain is dependent on the induction of leukocyte adhesion molecules and chemoattractant chemokines. Recent studies have suggested the astrocyte to be a key cell in mediating the inflammatory process in the brain and in expressing adhesion molecules and chemokines. Here I overview work in my laboratory and others that demonstrates interleukin-1 (IL-1) to be a key inducer of the expression of these molecules in astrocytes. The temporal expression is sustained in nature and this is due to prolonged activation of the transcription factor NFkappaB. The molecular basis to the sustained activation of NFkappaB is also discussed. The IL-1 signalling pathway thus emerges as a valuable therapeutic target in the treatment of presently incurable neuropathological conditions.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-10438951, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-10695731, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-10716256, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-10716257, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-10998424, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-11067942, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-11137152, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-11596126, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-12921904, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-1533967, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-1538783, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-15509551, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-1826616, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-2373990, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-3082983, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-3140380, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-3326824, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-6217550, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7521369, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7530745, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7536402, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7540265, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7569975, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7569976, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7706427, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7796813, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7867060, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7910170, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-7957109, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-8371761, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-8476577, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-8497253, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-8497281, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-8757015, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-9509763, http://linkedlifedata.com/resource/pubmed/commentcorrection/16185251-9831712
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-8782
pubmed:author
pubmed:issnType
Print
pubmed:volume
207
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
265-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The interleukin-1 signalling pathway in astrocytes: a key contributor to inflammation in the brain.
pubmed:affiliation
Department of Pharmacology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland. P.Moynagh@ucd.i.e
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't