16185190

Source:http://linkedlifedata.com/resource/pubmed/id/16185190

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0005854, umls-concept:C0026769, umls-concept:C0439662, umls-concept:C0699795, umls-concept:C0700114, umls-concept:C1261512, umls-concept:C1304680
pubmed:issue	2
pubmed:dateCreated	2005-9-27
pubmed:abstractText	Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS). The acquired immune system plays a central role in the pathogenesis of MS although target antigens and effector mechanisms are still poorly defined. Studies in animal models of infectious or autoimmune encephalomyelitis suggest that the acquired immune response targeting the CNS in MS originates from the periphery. Both T and B cells undergo activation and maturation in the lymphoid system allowing them to cross the blood brain barrier and infiltrate CNS tissue. Within the CNS, they require a local proinflammatory milieu contributed by macrophages and microglia to mediate their effector function which ultimately leads to damage of myelin sheath, oligodendrocytes, and neurons. In the current review, we elucidate the role of the immune system in MS with particular emphasis on activation and migration of immune cells to the CNS, the role of CNS cells in the inflammatory process and the contribution of the immune system to damage and repair. Based on these considerations we discuss new strategies to investigate pathogenetic pathways in multiple sclerosis.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101208439
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1567-2026
pubmed:author	pubmed-author:CepokSabineS, pubmed-author:HemmerBernhardB, pubmed-author:SommerNorbertN, pubmed-author:ZhouDunD
pubmed:issnType	Print
pubmed:volume	1
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	141-50
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:16185190-Animals, pubmed-meshheading:16185190-Blood-Brain Barrier, pubmed-meshheading:16185190-Humans, pubmed-meshheading:16185190-Immune System, pubmed-meshheading:16185190-Multiple Sclerosis
pubmed:year	2004
pubmed:articleTitle	Multiple sclerosis -- a coordinated immune attack across the blood brain barrier.
pubmed:affiliation	Heinrich-Heine-Universitat, MNR-Klinik Geb. 13.53, Klinik für Neurologie, Moorenstrasse 5, 40225 Düsseldorf, Germany. bernhard.hemmer@uni-duesseldorf.de
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't