16183563

Source:http://linkedlifedata.com/resource/pubmed/id/16183563

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021760, umls-concept:C0581603, umls-concept:C1274040, umls-concept:C1522318, umls-concept:C1882417
pubmed:issue	3
pubmed:dateCreated	2005-9-26
pubmed:abstractText	Levels of the proinflammatory cytokine interleukin 6 (IL-6) increase after surgery. The functional polymorphism in the IL-6 promoter region, G-174C, is associated with an increased risk of coronary heart disease. We investigated the genetic predisposition in IL-6 response to coronary revascularization and studied the association between the G-174C polymorphism, IL-6 levels, and clinical outcomes of surgery.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100891112
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Adenine, http://linkedlifedata.com/resource/pubmed/chemical/Guanine, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6
pubmed:status	MEDLINE
pubmed:issn	1522-6662
pubmed:author	pubmed-author:BarnardJamesJ, pubmed-author:BittarMohamad NMN, pubmed-author:CareyJohn AJA, pubmed-author:FildesJames EJE, pubmed-author:HutchinsonIan VIV, pubmed-author:PravicaVeraV, pubmed-author:YonanNizarN
pubmed:issnType	Electronic
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	E140-5; discussion E145
pubmed:meshHeading	pubmed-meshheading:16183563-Adenine, pubmed-meshheading:16183563-Aged, pubmed-meshheading:16183563-Alleles, pubmed-meshheading:16183563-Atrial Fibrillation, pubmed-meshheading:16183563-Blood Loss, Surgical, pubmed-meshheading:16183563-Coronary Artery Bypass, pubmed-meshheading:16183563-Coronary Disease, pubmed-meshheading:16183563-Female, pubmed-meshheading:16183563-Genetic Predisposition to Disease, pubmed-meshheading:16183563-Genotype, pubmed-meshheading:16183563-Guanine, pubmed-meshheading:16183563-Homozygote, pubmed-meshheading:16183563-Humans, pubmed-meshheading:16183563-Incidence, pubmed-meshheading:16183563-Interleukin-6, pubmed-meshheading:16183563-Length of Stay, pubmed-meshheading:16183563-Male, pubmed-meshheading:16183563-Middle Aged, pubmed-meshheading:16183563-Polymorphism, Genetic, pubmed-meshheading:16183563-Postoperative Period, pubmed-meshheading:16183563-Prospective Studies, pubmed-meshheading:16183563-Severity of Illness Index, pubmed-meshheading:16183563-Treatment Outcome
pubmed:year	2005
pubmed:articleTitle	Interleukin 6 G-174C polymorphism influences outcome following coronary revascularization surgery.
pubmed:affiliation	Department of Cardiothoracic Surgery, South Manchester University Hospitals NHS Trust, Manchester, UK. mbittar@doctors.org.uk
pubmed:publicationType	Journal Article