Linked Life Data

16182592

Source:http://linkedlifedata.com/resource/pubmed/id/16182592

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-30
pubmed:abstractText
The immunopathogenesis of leukopenia and thrombocytopenia in patients with severe acute respiratory syndrome (SARS) is unclear. In order to explore the leukopenia mechanism, we studied 15 SARS patients who were previously healthy, and 15 age-matched normal controls in a paired design. Soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble Fas ligand (sFasL) in plasma were measured by ELISA, and intracellular activated caspase-3 fragment in different leukocytes was determined by flow cytometry. Patients with SARS had significantly lower lymphocyte and platelet counts and significantly higher sVCAM-1 and sFasL levels compared to healthy controls. sVCAM-1 levels correlated negatively with total leukocytes and platelet counts, but positively with plasma sFasL levels. Intracellular cleaved caspase-3 expression was also significantly higher in lymphocytes from SARS patients in acute phase than in convalescent stage. Lymphopenia and thrombocytopenia in SARS patients may be caused, in part, by enhanced vascular sequestration associated with increased sVCAM-1 levels. However, lymphopenia may be due to enhanced cell death. Inhibition of cell adhesion and caspase-3 activation could, therefore, have prevented SARS patients from developing thrombocytopenia and lymphopenia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1286-4579
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
122-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16182592-Adult, pubmed-meshheading:16182592-Apoptosis, pubmed-meshheading:16182592-Case-Control Studies, pubmed-meshheading:16182592-Caspase 3, pubmed-meshheading:16182592-Caspases, pubmed-meshheading:16182592-Cell Adhesion Molecules, pubmed-meshheading:16182592-Fas Ligand Protein, pubmed-meshheading:16182592-Gene Expression Regulation, Enzymologic, pubmed-meshheading:16182592-Humans, pubmed-meshheading:16182592-Leukocytes, pubmed-meshheading:16182592-Lymphopenia, pubmed-meshheading:16182592-Membrane Glycoproteins, pubmed-meshheading:16182592-Middle Aged, pubmed-meshheading:16182592-Severe Acute Respiratory Syndrome, pubmed-meshheading:16182592-Thrombocytopenia, pubmed-meshheading:16182592-Tumor Necrosis Factors, pubmed-meshheading:16182592-Vascular Cell Adhesion Molecule-1
pubmed:year
2006
pubmed:articleTitle
Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS).
pubmed:affiliation
Department of Medical Research (12F12L), Chang Gung Memorial Hospital at Kaohsiung, 123 Ta-Pei Road, Niau-Sung, Kaohsiung 833, Taiwan, ROC.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't