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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-1-10
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pubmed:abstractText |
A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient age (P=0.006), but not with cytogenetic abnormalities. Patients with high levels of cyclin A1 had poorer event-free survival (57.9%) compared to patients with lower levels (75%).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
254-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16182364-Adolescent,
pubmed-meshheading:16182364-Age Factors,
pubmed-meshheading:16182364-Child,
pubmed-meshheading:16182364-Child, Preschool,
pubmed-meshheading:16182364-Chromosome Aberrations,
pubmed-meshheading:16182364-Cyclin A,
pubmed-meshheading:16182364-Cyclin A1,
pubmed-meshheading:16182364-Disease-Free Survival,
pubmed-meshheading:16182364-Female,
pubmed-meshheading:16182364-Gene Expression Regulation, Leukemic,
pubmed-meshheading:16182364-Humans,
pubmed-meshheading:16182364-Infant,
pubmed-meshheading:16182364-Male,
pubmed-meshheading:16182364-Neoplasm Proteins,
pubmed-meshheading:16182364-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:16182364-Predictive Value of Tests,
pubmed-meshheading:16182364-Tumor Markers, Biological
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pubmed:year |
2006
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pubmed:articleTitle |
Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.
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pubmed:affiliation |
Division of Pathology, Department of Laboratory Medicine, Lund University, University Hospital, 205 02 Malmö, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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