Linked Life Data

16181080

Source:http://linkedlifedata.com/resource/pubmed/id/16181080

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-9-26
pubmed:abstractText
In multicellular organisms, apoptosis, also known as programmed cell death, is an important physiological response to eliminate unnecessary, excess, or harmful cells. Apoptosis occurs during embryonic development and is important in maintaining homeostasis during adulthood. Apoptosis also plays critical roles in angiogenesis and vessel regression. During these processes, activation of the apoptotic signaling pathway in endothelial cells mediates cell death. Several molecules, including growth factors and cytokines, produced by endothelial cells and other cells, regulate endothelial cell survival and apoptosis. Understanding the regulation of apoptosis is of great importance for determining the physiological role of endothelial cells and for developing novel therapeutic strategies. This review highlights the rapidly accumulating knowledge regarding endothelial cell death and provides insight into the molecular mechanisms regulating apoptosis and survival of endothelial cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1567-2026
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Regulation of endothelial cell death and its role in angiogenesis and vascular regression.
pubmed:affiliation
Department of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan. ksakamak@virus.kyoto-u.ac.jp
pubmed:publicationType
Journal Article, Review