| pubmed-article:16179941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C0245662 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C1418556 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16179941 | lifeskim:mentions | umls-concept:C0913626 | lld:lifeskim |
| pubmed-article:16179941 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16179941 | pubmed:dateCreated | 2006-2-15 | lld:pubmed |
| pubmed-article:16179941 | pubmed:abstractText | Formation of the CD95 (APO-1/Fas) death inducing signaling complex (DISC) plays a central role in CD95 signaling. Previously, CD95 DISC composition was analyzed by two-dimensional gel electrophoresis and four major cytotoxicity-associated proteins (CAP1-4) were found. CAP1 and CAP2 were defined to be unmodified and phosphorylated FADD, respectively. CAP4 was identified as procaspase-8a. CAP3, however, has remained elusive. In this study, we demonstrate that CAP3 is an intermediate of procaspase-8 processing. CAP3 is generated within seconds of DISC formation and subsequently processed to the prodomain of procaspase-8a that is known as p26 (CAP5). These findings lead to new insights into the mechanism of procaspase-8 processing and apoptosis initiation. | lld:pubmed |
| pubmed-article:16179941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16179941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16179941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16179941 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16179941 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:16179941 | pubmed:author | pubmed-author:KrammerP HPH | lld:pubmed |
| pubmed-article:16179941 | pubmed:author | pubmed-author:SchmitzII | lld:pubmed |
| pubmed-article:16179941 | pubmed:author | pubmed-author:BrennerDD | lld:pubmed |
| pubmed-article:16179941 | pubmed:author | pubmed-author:KruegerAA | lld:pubmed |
| pubmed-article:16179941 | pubmed:author | pubmed-author:LavrikI NIN | lld:pubmed |
| pubmed-article:16179941 | pubmed:author | pubmed-author:WatzlCC | lld:pubmed |
| pubmed-article:16179941 | pubmed:author | pubmed-author:GolksAA | lld:pubmed |
| pubmed-article:16179941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16179941 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:16179941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16179941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16179941 | pubmed:pagination | 489-98 | lld:pubmed |
| pubmed-article:16179941 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16179941 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16179941 | pubmed:articleTitle | The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation. | lld:pubmed |
| pubmed-article:16179941 | pubmed:affiliation | Division of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. | lld:pubmed |
| pubmed-article:16179941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16179941 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:841 | entrezgene:pubmed | pubmed-article:16179941 | lld:entrezgene |
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