|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2006-2-15
|
|
pubmed:abstractText |
Formation of the CD95 (APO-1/Fas) death inducing signaling complex (DISC) plays a central role in CD95 signaling. Previously, CD95 DISC composition was analyzed by two-dimensional gel electrophoresis and four major cytotoxicity-associated proteins (CAP1-4) were found. CAP1 and CAP2 were defined to be unmodified and phosphorylated FADD, respectively. CAP4 was identified as procaspase-8a. CAP3, however, has remained elusive. In this study, we demonstrate that CAP3 is an intermediate of procaspase-8 processing. CAP3 is generated within seconds of DISC formation and subsequently processed to the prodomain of procaspase-8a that is known as p26 (CAP5). These findings lead to new insights into the mechanism of procaspase-8 processing and apoptosis initiation.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Chloromethyl Ketones,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Proteinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Death Domain Receptor Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/SERPINB9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serpins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/benzyloxycarbonylvalyl-alanyl-aspart...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
1350-9047
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
489-98
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16179941-Amino Acid Chloromethyl Ketones,
pubmed-meshheading:16179941-Antigens, CD95,
pubmed-meshheading:16179941-Apoptosis,
pubmed-meshheading:16179941-Caspase 8,
pubmed-meshheading:16179941-Caspases,
pubmed-meshheading:16179941-Cell Line,
pubmed-meshheading:16179941-Cysteine Proteinase Inhibitors,
pubmed-meshheading:16179941-Death Domain Receptor Signaling Adaptor Proteins,
pubmed-meshheading:16179941-Enzyme Activation,
pubmed-meshheading:16179941-Enzyme Precursors,
pubmed-meshheading:16179941-Humans,
pubmed-meshheading:16179941-Kinetics,
pubmed-meshheading:16179941-Models, Biological,
pubmed-meshheading:16179941-Protein Structure, Tertiary,
pubmed-meshheading:16179941-Serpins,
pubmed-meshheading:16179941-Signal Transduction,
pubmed-meshheading:16179941-Tumor Necrosis Factor Receptor-Associated Peptides and...
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation.
|
|
pubmed:affiliation |
Division of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
