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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-6
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pubmed:abstractText |
Mesangial cell (MC) proliferation underlies increased matrix accumulation in glomerulonephritis (GN), and the resolution of MC proliferation occurs largely through apoptosis. Proliferation and apoptosis are controlled by specific cell cycle proteins, where cyclin-dependent kinase (CDK) inhibitors such as p21 bind target cyclin-CDK complexes. However, the role of p21 in acute mesangial proliferative GN is not known. This study was conducted to test the hypothesis that p21 regulates MC proliferation and apoptosis in anti-MC serum-induced GN.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1660-2129
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pubmed:author |
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pubmed:copyrightInfo |
2006 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e8-18
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16179805-Animals,
pubmed-meshheading:16179805-Apoptosis,
pubmed-meshheading:16179805-Blood Urea Nitrogen,
pubmed-meshheading:16179805-Cell Proliferation,
pubmed-meshheading:16179805-Complement C3,
pubmed-meshheading:16179805-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:16179805-Fibrosis,
pubmed-meshheading:16179805-Glomerular Mesangium,
pubmed-meshheading:16179805-Glomerulonephritis, Membranoproliferative,
pubmed-meshheading:16179805-Immunoglobulin G,
pubmed-meshheading:16179805-Immunohistochemistry,
pubmed-meshheading:16179805-Kidney,
pubmed-meshheading:16179805-Kidney Glomerulus,
pubmed-meshheading:16179805-Kidney Tubules,
pubmed-meshheading:16179805-Macrophages,
pubmed-meshheading:16179805-Mice,
pubmed-meshheading:16179805-Mice, Inbred C57BL,
pubmed-meshheading:16179805-Mice, Knockout,
pubmed-meshheading:16179805-Neutrophils,
pubmed-meshheading:16179805-Proteinuria,
pubmed-meshheading:16179805-Sheep,
pubmed-meshheading:16179805-Staining and Labeling
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pubmed:year |
2006
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pubmed:articleTitle |
The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis.
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pubmed:affiliation |
Division of Nephrology, University of Washington, Seattle, Washington, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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