| pubmed-article:16179351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C1140680 | lld:lifeskim |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C1155312 | lld:lifeskim |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16179351 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16179351 | pubmed:issue | 47 | lld:pubmed |
| pubmed-article:16179351 | pubmed:dateCreated | 2005-11-21 | lld:pubmed |
| pubmed-article:16179351 | pubmed:abstractText | Superoxide dismutases (SODs) are important antioxidant enzymes responsible for the elimination of superoxide radical (O(2)(-)). The manganese-containing SOD (Mn-SOD) has been suggested to have tumor suppressor function and is located in the mitochondria where the majority of O(2)(-) is generated during respiration. Although increased reactive oxygen species (ROS) in cancer cells has long been recognized, the expression of Mn-SOD in cancer and its role in cancer development remain elusive. The present study used a human tissue microarray to analyze Mn-SOD expression in primary ovarian cancer tissues, benign ovarian lesions, and normal ovary epithelium. Significantly higher levels of Mn-SOD protein expression were detected in the malignant tissues compared with normal tissues (p < 0.05). In experimental systems, suppression of Mn-SOD expression by small interfering RNA caused a 70% increase of superoxide in ovarian cancer cells, leading to stimulation of cell proliferation in vitro and more aggressive tumor growth in vivo. Furthermore, stimulation of mitochondrial O(2)(-) production induced an increase of Mn-SOD expression. Our findings suggest that the increase in Mn-SOD expression in ovarian cancer is a cellular response to intrinsic ROS stress and that scavenging of superoxide by SOD may alleviate the ROS stress and thus reduce the simulating effect of ROS on cell growth. | lld:pubmed |
| pubmed-article:16179351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16179351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179351 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16179351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16179351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16179351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16179351 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16179351 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:16179351 | pubmed:author | pubmed-author:ZhouYanY | lld:pubmed |
| pubmed-article:16179351 | pubmed:author | pubmed-author:HuangPengP | lld:pubmed |
| pubmed-article:16179351 | pubmed:author | pubmed-author:LiuJinsongJ | lld:pubmed |
| pubmed-article:16179351 | pubmed:author | pubmed-author:LiFengF | lld:pubmed |
| pubmed-article:16179351 | pubmed:author | pubmed-author:YangGongG | lld:pubmed |
| pubmed-article:16179351 | pubmed:author | pubmed-author:RosenDaniel... | lld:pubmed |
| pubmed-article:16179351 | pubmed:author | pubmed-author:HuYuminY | lld:pubmed |
| pubmed-article:16179351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16179351 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:16179351 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:16179351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16179351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16179351 | pubmed:pagination | 39485-92 | lld:pubmed |
| pubmed-article:16179351 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16179351 | pubmed:meshHeading | pubmed-meshheading:16179351... | lld:pubmed |
| pubmed-article:16179351 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16179351 | pubmed:articleTitle | Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. | lld:pubmed |
| pubmed-article:16179351 | pubmed:affiliation | Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. | lld:pubmed |
| pubmed-article:16179351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16179351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16179351 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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