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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0013331,
umls-concept:C0019904,
umls-concept:C0025810,
umls-concept:C0037047,
umls-concept:C0871261,
umls-concept:C1263846,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2911692
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pubmed:issue |
10
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pubmed:dateCreated |
2005-9-23
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pubmed:abstractText |
A minority of patients with attention-deficit hyperactivity disorder (ADHD) do not respond favorably to methylphenidate. This has been partially associated with homozygosity for the Dopamine transporter (DAT1) 10-repeat allele and the presence of one or two Dopamine D4 receptor (DRD4) 7-repeat alleles. This study examined the sibling correlation of methylphenidate response rate and the possible association between response rate and these risk alleles.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9630
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1074-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16178931-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:16178931-Child,
pubmed-meshheading:16178931-Comorbidity,
pubmed-meshheading:16178931-Dopamine Agents,
pubmed-meshheading:16178931-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:16178931-Female,
pubmed-meshheading:16178931-Homozygote,
pubmed-meshheading:16178931-Humans,
pubmed-meshheading:16178931-Male,
pubmed-meshheading:16178931-Mental Disorders,
pubmed-meshheading:16178931-Methylphenidate,
pubmed-meshheading:16178931-Minisatellite Repeats,
pubmed-meshheading:16178931-Netherlands,
pubmed-meshheading:16178931-Polymorphism, Genetic,
pubmed-meshheading:16178931-Receptors, Dopamine D4,
pubmed-meshheading:16178931-Regression Analysis,
pubmed-meshheading:16178931-Retrospective Studies,
pubmed-meshheading:16178931-Risk,
pubmed-meshheading:16178931-Siblings
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pubmed:year |
2005
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pubmed:articleTitle |
High sibling correlation on methylphenidate response but no association with DAT1-10R homozygosity in Dutch sibpairs with ADHD.
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pubmed:affiliation |
Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Evandermeulen_2000@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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