|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2005-9-23
|
|
pubmed:abstractText |
Alterations in glucocorticoid hormone metabolism in skeletal muscle have been suggested to contribute to the pathogenesis of the metabolic syndrome. Circulating glucocorticoids consist of inactive cortisone and active cortisol interconverted in various tissues by the enzyme 11beta hydroxysteroid dehydrogenase (HSD). This study aims to investigate whether human myotubes established from healthy obese and matched obese type 2 diabetic (T2D) subjects reveal differences in the expression level of glucocorticoid receptor (GR) and 11beta hydroxysteroid dehydrogenase (HSD1 and HSD2), and to investigate whether chronic exposure to cortisone affects glucose transport.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/11-beta-Hydroxysteroid...,
http://linkedlifedata.com/resource/pubmed/chemical/11-beta-Hydroxysteroid...,
http://linkedlifedata.com/resource/pubmed/chemical/Carbenoxolone,
http://linkedlifedata.com/resource/pubmed/chemical/Cortisone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Orphan Nuclear Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucocorticoid,
http://linkedlifedata.com/resource/pubmed/chemical/glucocorticoid receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/liver X receptor
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0014-2972
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
35
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
627-34
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16178882-11-beta-Hydroxysteroid Dehydrogenase Type 1,
pubmed-meshheading:16178882-11-beta-Hydroxysteroid Dehydrogenase Type 2,
pubmed-meshheading:16178882-Carbenoxolone,
pubmed-meshheading:16178882-Cortisone,
pubmed-meshheading:16178882-DNA-Binding Proteins,
pubmed-meshheading:16178882-Diabetes Mellitus, Type 2,
pubmed-meshheading:16178882-Humans,
pubmed-meshheading:16178882-Hydrocortisone,
pubmed-meshheading:16178882-Insulin Resistance,
pubmed-meshheading:16178882-Middle Aged,
pubmed-meshheading:16178882-Muscle Fibers, Skeletal,
pubmed-meshheading:16178882-Obesity,
pubmed-meshheading:16178882-Orphan Nuclear Receptors,
pubmed-meshheading:16178882-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:16178882-Receptors, Glucocorticoid
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes.
|
|
pubmed:affiliation |
KMEB, Department of Endocrinology, Odense University Hospital, Denmark.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
