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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-9-23
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pubmed:abstractText |
Loss of peritoneal function is a major complication associated with long-term peritoneal dialysis. Observed changes include loss and degeneration of the mesothelium, submesothelial thickening, alterations in the structure and number of blood vessels, and reduplication of the vascular basement membrane. Exposure to high glucose concentrations in peritoneal dialysis solutions is known to cause injury to cultured human peritoneal mesothelial cells (HPMC) as a result of overexpression of transforming growth factor beta 1 (TGF-beta1). Previous studies have demonstrated that angiotensin II (AII) increases expression of TGF-beta1 in a number of different cell types; although this has not been demonstrated in HPMC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II Type 1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Dialysis Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/candesartan,
http://linkedlifedata.com/resource/pubmed/chemical/perindoprilat
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pubmed:status |
MEDLINE
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pubmed:issn |
0896-8608
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
483-91
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16178483-Angiotensin II,
pubmed-meshheading:16178483-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:16178483-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:16178483-Benzimidazoles,
pubmed-meshheading:16178483-Cell Culture Techniques,
pubmed-meshheading:16178483-Cell Proliferation,
pubmed-meshheading:16178483-Dialysis Solutions,
pubmed-meshheading:16178483-Dose-Response Relationship, Drug,
pubmed-meshheading:16178483-Epithelial Cells,
pubmed-meshheading:16178483-Glucose,
pubmed-meshheading:16178483-Humans,
pubmed-meshheading:16178483-Indoles,
pubmed-meshheading:16178483-Peritoneal Cavity,
pubmed-meshheading:16178483-RNA, Messenger,
pubmed-meshheading:16178483-Tetrazoles,
pubmed-meshheading:16178483-Transforming Growth Factor beta,
pubmed-meshheading:16178483-Transforming Growth Factor beta1
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pubmed:articleTitle |
Tgf-beta1 induced by high glucose is controlled by angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker on cultured human peritoneal mesothelial cells.
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pubmed:affiliation |
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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