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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-9-22
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pubmed:abstractText |
Recombinant adeno-associated viral (rAAV) vectors currently show promise for islet gene therapy. In the presence of complementing AAV2 Rep proteins, AAV2 genomes can be packaged with other serotype capsids to assemble infectious virions. During transduction, the ssDNA to dsDNA conversion is one of the major rate-limiting steps that contribute to the slow onset of transgene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0041-1337
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
683-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16177645-Adenoviridae,
pubmed-meshheading:16177645-Animals,
pubmed-meshheading:16177645-Capsid,
pubmed-meshheading:16177645-DNA,
pubmed-meshheading:16177645-DNA, Single-Stranded,
pubmed-meshheading:16177645-Diabetes Mellitus, Experimental,
pubmed-meshheading:16177645-Gene Therapy,
pubmed-meshheading:16177645-Genes, Reporter,
pubmed-meshheading:16177645-Genome, Viral,
pubmed-meshheading:16177645-Green Fluorescent Proteins,
pubmed-meshheading:16177645-Humans,
pubmed-meshheading:16177645-Islets of Langerhans,
pubmed-meshheading:16177645-Islets of Langerhans Transplantation,
pubmed-meshheading:16177645-Mice,
pubmed-meshheading:16177645-Mice, Inbred BALB C,
pubmed-meshheading:16177645-Mice, SCID,
pubmed-meshheading:16177645-Transduction, Genetic,
pubmed-meshheading:16177645-Transgenes,
pubmed-meshheading:16177645-Transplantation, Heterologous
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pubmed:year |
2005
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pubmed:articleTitle |
Transduction of pancreatic islets with pseudotyped adeno-associated virus: effect of viral capsid and genome conversion.
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pubmed:affiliation |
Recanati-Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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