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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-10-10
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pubmed:abstractText |
Testicular development is arrested in the hypogonadal (hpg) mouse due to a congenital deficiency in hypothalamic gonadotropin-releasing hormone (GnRH) synthesis. Chronic treatment of male hpg mice with estradiol induces FSH synthesis and secretion, and causes testicular maturation and qualitatively normal spermatogenesis. As estradiol negative feedback normally inhibits FSH production in the male, this study tested whether this paradoxical response to estradiol in the male hpg mouse might be due to inadequate masculinisation or incomplete defeminization in the neonatal period. Previous studies have demonstrated that treatment of hpg mice with testosterone propionate in the immediate neonatal period is necessary to allow full reproductive behaviors to be expressed following suitable endocrine stimulation at adult ages.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-10393934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-10599737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-10775161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-10919273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-11014247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-11201285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-11403898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-11943512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-12598657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-12788908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-1391342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-15056765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-2780856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-3121284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-4334848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-5166472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-6271539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-6690645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-8248223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-8943767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-923739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16176578-9393999
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1477-7827
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
48
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16176578-Androgens,
pubmed-meshheading:16176578-Animals,
pubmed-meshheading:16176578-Animals, Newborn,
pubmed-meshheading:16176578-Cholesterol,
pubmed-meshheading:16176578-Estradiol,
pubmed-meshheading:16176578-Female,
pubmed-meshheading:16176578-Follicle Stimulating Hormone,
pubmed-meshheading:16176578-Hypogonadism,
pubmed-meshheading:16176578-Male,
pubmed-meshheading:16176578-Mice,
pubmed-meshheading:16176578-Mice, Inbred C3H,
pubmed-meshheading:16176578-Mice, Mutant Strains,
pubmed-meshheading:16176578-Organ Size,
pubmed-meshheading:16176578-Sexual Behavior, Animal,
pubmed-meshheading:16176578-Spermatogenesis,
pubmed-meshheading:16176578-Testis,
pubmed-meshheading:16176578-Testosterone Propionate
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pubmed:year |
2005
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pubmed:articleTitle |
Neonatal androgenization of hypogonadal (hpg) male mice does not abolish estradiol-induced FSH production and spermatogenesis.
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pubmed:affiliation |
School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK. margaret.nwagwu@nottingham.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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