Source:http://linkedlifedata.com/resource/pubmed/id/16176153
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-9-22
|
| pubmed:abstractText |
Chronic administration of ethanol (2 g/kg, p.o.) on days 1-6 and its withdrawal produced an anxiogenic reaction in mice as assessed in the mirrored-chamber test. Daily administration of quercetin (25 or 50 mg/kg, p.o.) prior to ethanol for 6 days prevented withdrawal-induced anxiety in mice. However, acute administration of a single dose of quercetin (50 mg/kg) to animals withdrawn from ethanol, i.e., on day 7, did not prevent withdrawal-induced anxiety. Ethanol withdrawal also induced a significant increase in the locomotor activity of mice indicating an anxiogenic response. Daily administration of quercetin (25 or 50 mg/kg, p.o.) prior to ethanol for 6 days prevented withdrawal-induced increased locomotor activity. Ethanol withdrawal also sensitized the convulsogenic reaction to pentylenetetrazole (PTZ). A non-convulsive dose (40-60 mg/kg) of PTZ produced full-blown convulsions and increased mortality in ethanol-withdrawn mice. Both acute and chronic administration of quercetin (25 or 50 mg/kg, p.o.) produced a significant protection against ethanol withdrawal-induced reduction in PTZ threshold in mice. The result suggests the protective effect of this safe drug, quercetin, in the management of ethanol withdrawal reactions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1096-620X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
392-6
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:16176153-Alcohol Withdrawal Seizures,
pubmed-meshheading:16176153-Animals,
pubmed-meshheading:16176153-Anxiety,
pubmed-meshheading:16176153-Ethanol,
pubmed-meshheading:16176153-Female,
pubmed-meshheading:16176153-Hyperkinesis,
pubmed-meshheading:16176153-Male,
pubmed-meshheading:16176153-Mice,
pubmed-meshheading:16176153-Motor Activity,
pubmed-meshheading:16176153-Pentylenetetrazole,
pubmed-meshheading:16176153-Quercetin,
pubmed-meshheading:16176153-Seizures,
pubmed-meshheading:16176153-Substance Withdrawal Syndrome
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Protective effect of quercetin on alcohol abstinence-induced anxiety and convulsions.
|
| pubmed:affiliation |
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
|
| pubmed:publicationType |
Journal Article
|