|
rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020672,
umls-concept:C0038454,
umls-concept:C0087111,
umls-concept:C0145946,
umls-concept:C0185117,
umls-concept:C0205217,
umls-concept:C0301630,
umls-concept:C0441889,
umls-concept:C0547040,
umls-concept:C0623362,
umls-concept:C0871261,
umls-concept:C1517004,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2005-9-22
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pubmed:abstractText |
Mild hypothermia is a robust neuroprotectant, and the results of prospective clinical trials have indicated that it may improve neurological outcome in certain instances. One aspect of this protection has been associated with the prevention of blood-brain barrier (BBB) disruption. Matrix metalloproteinases (MMPs) have been implicated in BBB disruption because they can degrade the extracellular matrix. In this study the authors explored the relationship between hypothermia and MMPs and whether BBB preservation resulting from mild hypothermia therapy is due to alterations in MMP expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-3085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-97
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16175859-Animals,
pubmed-meshheading:16175859-Blood-Brain Barrier,
pubmed-meshheading:16175859-Down-Regulation,
pubmed-meshheading:16175859-Hypothermia, Induced,
pubmed-meshheading:16175859-Male,
pubmed-meshheading:16175859-Matrix Metalloproteinases,
pubmed-meshheading:16175859-Rats,
pubmed-meshheading:16175859-Rats, Sprague-Dawley,
pubmed-meshheading:16175859-Stroke,
pubmed-meshheading:16175859-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:16175859-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke.
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pubmed:affiliation |
Departments of Neurosurgery, Neurology, and Radiology, Stanford University, Stanford, California, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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