Linked Life Data

16174954

Source:http://linkedlifedata.com/resource/pubmed/id/16174954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-9-21
pubmed:abstractText
Abnormalities in blood coagulation, although quite common after traumatic brain injury (TBI), are of unknown significance. The authors review the clinical and pathophysiological features of this phenomenon and emphasize its origin in disseminated intravascular coagulation. This connection provides a possible explanation for much of the cerebral ischemia that accompanies TBI, namely intravascular microthrombosis. The authors' own research findings support this contention and suggest possible therapeutic avenues. A number of compelling studies demonstrate that DIC is a common and important consequence of TBI. In particular, posttraumatic coagulopathy appears to be linked to secondary cerebral injury. Although the extent of this process has yet to be elucidated fully, coagulation abnormalities are evident soon after trauma. This allows early identification of patients likely to suffer secondary complications and provides an opportunity to evaluate promising agents that may mitigate posttraumatic DIC and related pathologies in these patients. This is an area deserving of more intensive research.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1541-6933
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
479-88
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Coagulopathy in traumatic brain injury.
pubmed:affiliation
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. sherman.stein@uphs.upenn.edu
pubmed:publicationType
Journal Article, Review