|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
|
|
pubmed:dateCreated |
2005-9-21
|
|
pubmed:abstractText |
Sporadic colorectal cancers often arise from a region of cells characterized by a "field defect" that has not been well defined molecularly. DNA methylation has been proposed as a candidate mediator of this field defect. The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is frequently methylated in colorectal cancer. We hypothesized that MGMT methylation could be one of the mediators of field cancerization in the colon mucosa.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1460-2105
|
|
pubmed:author |
pubmed-author:AlbertsDavid SDS,
pubmed-author:BuckmeierJulieJ,
pubmed-author:EinspahrJanine GJG,
pubmed-author:HamiltonStanley RSR,
pubmed-author:HernandezNatalie SupunpongNS,
pubmed-author:HoulihanP ScottPS,
pubmed-author:IssaJean-Pierre JJP,
pubmed-author:KondoYutakaY,
pubmed-author:KrouseRobert SRS,
pubmed-author:LianchunXiaoX,
pubmed-author:PrasadAnil RAR,
pubmed-author:RosnerGary LGL,
pubmed-author:ShenLanlanL,
pubmed-author:VilaythongJillJ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
21
|
|
pubmed:volume |
97
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1330-8
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:16174854-Cell Line, Tumor,
pubmed-meshheading:16174854-Colorectal Neoplasms,
pubmed-meshheading:16174854-DNA Methylation,
pubmed-meshheading:16174854-Epigenesis, Genetic,
pubmed-meshheading:16174854-Gene Silencing,
pubmed-meshheading:16174854-Humans,
pubmed-meshheading:16174854-Intestinal Mucosa,
pubmed-meshheading:16174854-Mutation,
pubmed-meshheading:16174854-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:16174854-Polymerase Chain Reaction,
pubmed-meshheading:16174854-Promoter Regions, Genetic,
pubmed-meshheading:16174854-Proto-Oncogene Proteins,
pubmed-meshheading:16174854-Risk Factors,
pubmed-meshheading:16174854-Sensitivity and Specificity,
pubmed-meshheading:16174854-Sequence Analysis, DNA,
pubmed-meshheading:16174854-Sulfites,
pubmed-meshheading:16174854-Tumor Markers, Biological,
pubmed-meshheading:16174854-Tumor Suppressor Protein p53,
pubmed-meshheading:16174854-ras Proteins
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
MGMT promoter methylation and field defect in sporadic colorectal cancer.
|
|
pubmed:affiliation |
Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
|
