Source:http://linkedlifedata.com/resource/pubmed/id/16173966
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-9-21
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pubmed:abstractText |
Nephrotic syndrome (NS) is an extremely rare complication of myeloablative allogeneic haematopoietic cell transplantation (HCT) that usually occurs in association with chronic graft-versus-host disease (C-GVHD). We observed an unexpectedly high incidence of NS in a cohort of 163 consecutive patients undergoing non-myeloablative HCT from a related human leucocyte antigen-compatible donor. Seven patients developed NS at a median 318 d post-transplant (range 119-1203 d; cumulative incidence 6.1%). The median age at onset of NS was 46 years (range 33-59 years); three of the seven patients had no evidence of C-GVHD while four had accompanying limited C-GVHD. At diagnosis, median proteinuria was 16.5 g/24 h (range 3-24 g/24 h). Renal biopsy was performed in four cases and revealed membranous nephropathy. NS was not always associated with other symptoms of C-GVHD, and in contrast to previous reports, usually did not improve with the re-initiation of aggressive immunosuppression, resulting in progressive renal failure necessitating dialysis in three of seven cases. Membranous nephropathy resulting in NS is a previously unrecognised and clinically significant complication of non-myeloablative HCT.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-9
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pubmed:dateRevised |
2007-4-30
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pubmed:meshHeading |
pubmed-meshheading:16173966-Adolescent,
pubmed-meshheading:16173966-Adult,
pubmed-meshheading:16173966-Aged,
pubmed-meshheading:16173966-Chronic Disease,
pubmed-meshheading:16173966-Cyclophosphamide,
pubmed-meshheading:16173966-Female,
pubmed-meshheading:16173966-Graft vs Host Disease,
pubmed-meshheading:16173966-Hematologic Neoplasms,
pubmed-meshheading:16173966-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:16173966-Humans,
pubmed-meshheading:16173966-Immunosuppressive Agents,
pubmed-meshheading:16173966-Kidney Failure, Chronic,
pubmed-meshheading:16173966-Kidney Glomerulus,
pubmed-meshheading:16173966-Male,
pubmed-meshheading:16173966-Middle Aged,
pubmed-meshheading:16173966-Nephrotic Syndrome,
pubmed-meshheading:16173966-Proteinuria,
pubmed-meshheading:16173966-T-Lymphocytes,
pubmed-meshheading:16173966-Time Factors,
pubmed-meshheading:16173966-Transplantation, Homologous,
pubmed-meshheading:16173966-Transplantation Conditioning,
pubmed-meshheading:16173966-Vidarabine
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pubmed:year |
2005
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pubmed:articleTitle |
Nephrotic syndrome: an under-recognised immune-mediated complication of non-myeloablative allogeneic haematopoietic cell transplantation.
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pubmed:affiliation |
Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892-1652, USA.
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pubmed:publicationType |
Journal Article
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