Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-9-21
pubmed:abstractText
Nephrotic syndrome (NS) is an extremely rare complication of myeloablative allogeneic haematopoietic cell transplantation (HCT) that usually occurs in association with chronic graft-versus-host disease (C-GVHD). We observed an unexpectedly high incidence of NS in a cohort of 163 consecutive patients undergoing non-myeloablative HCT from a related human leucocyte antigen-compatible donor. Seven patients developed NS at a median 318 d post-transplant (range 119-1203 d; cumulative incidence 6.1%). The median age at onset of NS was 46 years (range 33-59 years); three of the seven patients had no evidence of C-GVHD while four had accompanying limited C-GVHD. At diagnosis, median proteinuria was 16.5 g/24 h (range 3-24 g/24 h). Renal biopsy was performed in four cases and revealed membranous nephropathy. NS was not always associated with other symptoms of C-GVHD, and in contrast to previous reports, usually did not improve with the re-initiation of aggressive immunosuppression, resulting in progressive renal failure necessitating dialysis in three of seven cases. Membranous nephropathy resulting in NS is a previously unrecognised and clinically significant complication of non-myeloablative HCT.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
131
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
74-9
pubmed:dateRevised
2007-4-30
pubmed:meshHeading
pubmed-meshheading:16173966-Adolescent, pubmed-meshheading:16173966-Adult, pubmed-meshheading:16173966-Aged, pubmed-meshheading:16173966-Chronic Disease, pubmed-meshheading:16173966-Cyclophosphamide, pubmed-meshheading:16173966-Female, pubmed-meshheading:16173966-Graft vs Host Disease, pubmed-meshheading:16173966-Hematologic Neoplasms, pubmed-meshheading:16173966-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:16173966-Humans, pubmed-meshheading:16173966-Immunosuppressive Agents, pubmed-meshheading:16173966-Kidney Failure, Chronic, pubmed-meshheading:16173966-Kidney Glomerulus, pubmed-meshheading:16173966-Male, pubmed-meshheading:16173966-Middle Aged, pubmed-meshheading:16173966-Nephrotic Syndrome, pubmed-meshheading:16173966-Proteinuria, pubmed-meshheading:16173966-T-Lymphocytes, pubmed-meshheading:16173966-Time Factors, pubmed-meshheading:16173966-Transplantation, Homologous, pubmed-meshheading:16173966-Transplantation Conditioning, pubmed-meshheading:16173966-Vidarabine
pubmed:year
2005
pubmed:articleTitle
Nephrotic syndrome: an under-recognised immune-mediated complication of non-myeloablative allogeneic haematopoietic cell transplantation.
pubmed:affiliation
Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892-1652, USA.
pubmed:publicationType
Journal Article