Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-30
pubmed:databankReference
pubmed:abstractText
The Q gene is largely responsible for the widespread cultivation of wheat because it confers the free-threshing character. It also pleiotropically influences many other domestication-related traits such as glume shape and tenacity, rachis fragility, spike length, plant height, and spike emergence time. We isolated the Q gene and verified its identity by analysis of knockout mutants and transformation. The Q gene has a high degree of similarity to members of the AP2 family of transcription factors. The Q allele is more abundantly transcribed than q, and the two alleles differ for a single amino acid. An isoleucine at position 329 in the Q protein leads to an abundance of homodimer formation in yeast cells, whereas a valine in the q protein appears to limit homodimer formation. Ectopic expression analysis allowed us to observe both silencing and overexpression effects of Q. Rachis fragility, glume shape, and glume tenacity mimicked the q phenotype in transgenic plants exhibiting post-transcriptional silencing of the transgene and the endogenous Q gene. Variation in spike compactness and plant height were associated with the level of transgene transcription due to the dosage effects of Q. The q allele is the more primitive, and the mutation that gave rise to Q occurred only once leading to the world's cultivated wheats.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-10655233, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-11846609, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-12175074, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-12750342, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-12807786, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-12830387, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-12893888, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-13679977, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-14945063, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-15020705, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-1675158, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-1983792, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-2535466, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-7919989, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-9254694, http://linkedlifedata.com/resource/pubmed/commentcorrection/16172507-9553044
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
172
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-55
pubmed:dateRevised
2010-9-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Molecular characterization of the major wheat domestication gene Q.
pubmed:affiliation
Department of Plant Sciences, North Dakota State University, Fargo, North Dakota 58105, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.