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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-30
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pubmed:abstractText |
The DDK syndrome is an early embryonic lethal phenotype observed in crosses between females of the DDK inbred mouse strain and many non-DDK males. Lethality results from an incompatibility between a maternal DDK factor and a non-DDK paternal gene, both of which have been mapped to the Ovum mutant (Om) locus on mouse chromosome 11. Here we define a 465-kb candidate interval for the paternal gene by recombinant progeny testing. To further refine the candidate interval we determined whether males from 17 classical and wild-derived inbred strains are interfertile with DDK females. We conclude that the incompatible paternal allele arose in the Mus musculus domesticus lineage and that incompatible strains should share a common haplotype spanning the paternal gene. We tested for association between paternal allele compatibility/incompatibility and 167 genetic variants located in the candidate interval. Two diallelic SNPs, located in the Schlafen gene cluster, are completely predictive of the polar-lethal phenotype. These SNPs also predict the compatible or incompatible status of males of five additional strains.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16172501-10337624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16172501-10628992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16172501-10655231,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16172501-9846487
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0016-6731
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pubmed:author |
pubmed-author:BellTimothy ATA,
pubmed-author:DohertyHeather EHE,
pubmed-author:IderaabdullahFolamiF,
pubmed-author:KimKuikwonK,
pubmed-author:LangeEthan MEM,
pubmed-author:LangeLeslie ALA,
pubmed-author:SapienzaCarmenC,
pubmed-author:WangYunfeiY,
pubmed-author:WilhemsenKirkK,
pubmed-author:de VillenaFernando Pardo-ManuelFP,
pubmed-author:de la Casa-EsperónElenaE
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pubmed:issnType |
Print
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pubmed:volume |
172
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
411-23
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16172501-Animals,
pubmed-meshheading:16172501-Cell Cycle Proteins,
pubmed-meshheading:16172501-Chromosome Mapping,
pubmed-meshheading:16172501-Chromosomes,
pubmed-meshheading:16172501-Crosses, Genetic,
pubmed-meshheading:16172501-Female,
pubmed-meshheading:16172501-Fertility,
pubmed-meshheading:16172501-Genes, Lethal,
pubmed-meshheading:16172501-Genetic Linkage,
pubmed-meshheading:16172501-Genomic Imprinting,
pubmed-meshheading:16172501-Haplotypes,
pubmed-meshheading:16172501-Male,
pubmed-meshheading:16172501-Mice,
pubmed-meshheading:16172501-Mice, Inbred Strains,
pubmed-meshheading:16172501-Multigene Family,
pubmed-meshheading:16172501-Phenotype,
pubmed-meshheading:16172501-Phylogeny,
pubmed-meshheading:16172501-Syndrome
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pubmed:year |
2006
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pubmed:articleTitle |
The paternal gene of the DDK syndrome maps to the Schlafen gene cluster on mouse chromosome 11.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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