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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-9-19
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pubmed:abstractText |
Twenty male Wistar rats were trained under an alternating-lever cyclic-ratio (ALCR) schedule of food reinforcement. When responding showed no trends, each subject was subcutaneously implanted with an Alzet osmotic mini-pump, connected to a chronic indwelling cannula extending into the lateral ventricle of the brain. The mini-pumps were primed to infuse 0.25 microl lipopolysaccharide (LPS) (1.0 microg/0.25 ml) or 0.25 microl artificial cerebrospinal fluid (aCSF) per hour and were implanted for 28 days. LPS infusion produced behavioural deficits which chronic ibuprofen treatment (40 mg/kg every 12 h) alleviated. Infusion of LPS induced R 1282-positive amyloid deposits, and activation of microglia and astrocytes. Ibuprofen treatment reduced the numbers of activated microglia, and withdrawal of ibuprofen resulted in an increase in activated microglia; however, ibuprofen treatment had no effect on numbers of activated astrocytes in the LPS-infused subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0955-8810
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-41
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16170230-Amyloid beta-Peptides,
pubmed-meshheading:16170230-Animals,
pubmed-meshheading:16170230-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16170230-Antigens,
pubmed-meshheading:16170230-Astrocytes,
pubmed-meshheading:16170230-Behavior, Animal,
pubmed-meshheading:16170230-Brain,
pubmed-meshheading:16170230-Food,
pubmed-meshheading:16170230-Glial Fibrillary Acidic Protein,
pubmed-meshheading:16170230-Ibuprofen,
pubmed-meshheading:16170230-Immunohistochemistry,
pubmed-meshheading:16170230-Injections, Intraventricular,
pubmed-meshheading:16170230-Lipopolysaccharides,
pubmed-meshheading:16170230-Male,
pubmed-meshheading:16170230-Memory,
pubmed-meshheading:16170230-Microglia,
pubmed-meshheading:16170230-Neurofibrillary Tangles,
pubmed-meshheading:16170230-Rats,
pubmed-meshheading:16170230-Rats, Wistar,
pubmed-meshheading:16170230-Reinforcement (Psychology),
pubmed-meshheading:16170230-Reinforcement Schedule
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pubmed:year |
2005
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pubmed:articleTitle |
Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates.
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pubmed:affiliation |
School of Psychology, University of Ulster, Shore Road, Newtownabbey, Co. Antrim, N. Ireland, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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