Source:http://linkedlifedata.com/resource/pubmed/id/16169719
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
22
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| pubmed:dateCreated |
2005-10-5
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| pubmed:abstractText |
A series of novel xanthenone aminoderivatives and their pyrazole-fused counterparts possessing structural analogy to the potent anticancer agent 9-methoxypyrazoloacridine (PZA) reported. These compounds exhibited an interesting cytotoxic activity against a panel of cell lines. Most noticeably, they retain activity against the multidrug resistant MES-SA/Dx5 subline, showing resistant factors close to 1.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5057-60
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| pubmed:meshHeading |
pubmed-meshheading:16169719-Amination,
pubmed-meshheading:16169719-Animals,
pubmed-meshheading:16169719-Cell Line, Tumor,
pubmed-meshheading:16169719-Cell Proliferation,
pubmed-meshheading:16169719-Drug Design,
pubmed-meshheading:16169719-Drug Resistance, Multiple,
pubmed-meshheading:16169719-Humans,
pubmed-meshheading:16169719-Inhibitory Concentration 50,
pubmed-meshheading:16169719-Mice,
pubmed-meshheading:16169719-Molecular Structure,
pubmed-meshheading:16169719-Pyrazoles,
pubmed-meshheading:16169719-Xanthenes
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| pubmed:year |
2005
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| pubmed:articleTitle |
Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells.
|
| pubmed:affiliation |
Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
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| pubmed:publicationType |
Journal Article
|