| pubmed-article:16168397 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16168397 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16168397 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:16168397 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:16168397 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:16168397 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16168397 | pubmed:dateCreated | 2005-11-15 | lld:pubmed |
| pubmed-article:16168397 | pubmed:abstractText | Insulin-like growth factor (IGF)-I is known to act on fibroblasts as a progression factor to push cells toward proliferation and activation to synthesize collagen. Subepithelial fibrosis, collagen deposition at the lamina reticularis, is part of the process of so-called remodeling and is a characteristic finding in the asthmatic airway. To study the role of IGF in the evolution of asthma, we used a model that involved immunization of mice with ovalbumin and alum, followed by an inhaled challenge of ovalbumin. IGF-I neutralizing antibody was continuously infused with an osmotic pump. Pulmonary function was analyzed using whole-body plethysmography before and after acetylcholine administration. It was found that OVA inhalation induced IGF-I expression at the site of the airway. IGF-I neutralizing Ab inhibited the elevation of airway resistance, airway inflammation, and an increase in airway wall thickening. The depression of ICAM-1 expression was accompanied by a diminution in airway inflammation. In conclusion, these results suggest that IGF-I is likely to be an important mediator of inflammation and remodeling in the asthmatic airway. | lld:pubmed |
| pubmed-article:16168397 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16168397 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16168397 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16168397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16168397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16168397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16168397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16168397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16168397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16168397 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16168397 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16168397 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:OhtaKenK | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:NagaseHiroyuk... | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:AraiHidenoriH | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:AdachiTetsuya... | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:NaomiYamashit... | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:TashimoHiroyu... | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:IshidaHirofun... | lld:pubmed |
| pubmed-article:16168397 | pubmed:author | pubmed-author:MatsuoYukikoY | lld:pubmed |
| pubmed-article:16168397 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16168397 | pubmed:volume | 235 | lld:pubmed |
| pubmed-article:16168397 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16168397 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16168397 | pubmed:pagination | 85-91 | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:meshHeading | pubmed-meshheading:16168397... | lld:pubmed |
| pubmed-article:16168397 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16168397 | pubmed:articleTitle | Role of insulin-like growth factor-I in allergen-induced airway inflammation and remodeling. | lld:pubmed |
| pubmed-article:16168397 | pubmed:affiliation | Department of Pharmacology, Research Institute of Pharmaceutical Sciences, Musashino University, Japan. | lld:pubmed |
| pubmed-article:16168397 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:16000 | entrezgene:pubmed | pubmed-article:16168397 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16168397 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16168397 | lld:pubmed |
