Linked Life Data

16166593

Source:http://linkedlifedata.com/resource/pubmed/id/16166593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-10
pubmed:abstractText
We showed previously that mild real hypoxia and hypoxia-mimetic agents induced in vitro cell differentiation of acute myeloid leukemia (AML). We here investigate the in vivo effects of intermittent hypoxia on syngenic grafts of leukemic blasts in a PML-RARalpha transgenic mouse model of AML. For intermittent hypoxia, leukemic mice were housed in a hypoxia chamber equivalent to an altitude of 6000 m for 18 hours every consecutive day. The results show that intermittent hypoxia significantly prolongs the survival of the leukemic mice that received transplants, although it fails to cure the disease. By histologic and cytologic analyses, intermittent hypoxia is shown to inhibit the infiltration of leukemic blasts in peripheral blood, bone marrow, spleen, and liver without apoptosis induction. More intriguingly, intermittent hypoxia also induces leukemic cells to undergo differentiation with progressive increase of hypoxia-inducible factor-1alpha protein, as evidenced by morphologic criteria of maturating myeloid cells and increased expression of mouse myeloid cell differentiation-related antigens Gr-1 and Mac-1. Taken together, this study represents the first attempt to characterize the in vivo effects of hypoxia on an AML mouse model. Additional investigations may uncover ways to mimic the differentiative effects of hypoxia in a manner that will benefit human patients with AML.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
698-707
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16166593-Animals, pubmed-meshheading:16166593-Apoptosis, pubmed-meshheading:16166593-Blast Crisis, pubmed-meshheading:16166593-Bone Marrow, pubmed-meshheading:16166593-Cell Differentiation, pubmed-meshheading:16166593-Cell Hypoxia, pubmed-meshheading:16166593-Cobalt, pubmed-meshheading:16166593-Graft vs Leukemia Effect, pubmed-meshheading:16166593-Hypoxia-Inducible Factor 1, alpha Subunit, pubmed-meshheading:16166593-Leukemia, Myeloid, Acute, pubmed-meshheading:16166593-Liver, pubmed-meshheading:16166593-Macrophage-1 Antigen, pubmed-meshheading:16166593-Mice, pubmed-meshheading:16166593-Mice, Transgenic, pubmed-meshheading:16166593-Models, Animal, pubmed-meshheading:16166593-Myeloid Cells, pubmed-meshheading:16166593-Neoplasm Proteins, pubmed-meshheading:16166593-Oncogene Proteins, Fusion, pubmed-meshheading:16166593-Receptors, Chemokine, pubmed-meshheading:16166593-Spleen, pubmed-meshheading:16166593-Survival Rate, pubmed-meshheading:16166593-Tumor Cells, Cultured
pubmed:year
2006
pubmed:articleTitle
Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.
pubmed:affiliation
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't