|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
18
|
|
pubmed:dateCreated |
2005-9-16
|
|
pubmed:abstractText |
Bryostatin 1, a unique protein kinase C (PKC) activator, is already in the clinical trials. An understanding of complex regulation of PKC by bryostatin 1 is essential for effective use of bryostatin 1 in the clinic. We have previously shown that the ability of bryostatin 1 to enhance cisplatin sensitivity correlated with its ability to down-regulate PKCdelta in HeLa cells. We have investigated how bryostatin 1 influences PKCdelta regulation in cisplatin-resistant HeLa (HeLa/CP) cells, and if bryostatin 1 could be used to reverse cisplatin resistance.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Bryostatins,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams,
http://linkedlifedata.com/resource/pubmed/chemical/Macrolides,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol 12,13-Dibutyrate,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-delta,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/bryostatin 1,
http://linkedlifedata.com/resource/pubmed/chemical/indolactam V
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6730-7
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16166454-Antineoplastic Agents,
pubmed-meshheading:16166454-Apoptosis,
pubmed-meshheading:16166454-Blotting, Western,
pubmed-meshheading:16166454-Bryostatins,
pubmed-meshheading:16166454-Caspase 3,
pubmed-meshheading:16166454-Caspases,
pubmed-meshheading:16166454-Cell Survival,
pubmed-meshheading:16166454-Cisplatin,
pubmed-meshheading:16166454-Dose-Response Relationship, Drug,
pubmed-meshheading:16166454-Down-Regulation,
pubmed-meshheading:16166454-Drug Resistance, Neoplasm,
pubmed-meshheading:16166454-Drug Synergism,
pubmed-meshheading:16166454-Enzyme Activation,
pubmed-meshheading:16166454-Female,
pubmed-meshheading:16166454-HeLa Cells,
pubmed-meshheading:16166454-Humans,
pubmed-meshheading:16166454-Indoles,
pubmed-meshheading:16166454-Lactams,
pubmed-meshheading:16166454-Macrolides,
pubmed-meshheading:16166454-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:16166454-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:16166454-Protein Kinase C,
pubmed-meshheading:16166454-Protein Kinase C-alpha,
pubmed-meshheading:16166454-Protein Kinase C-delta,
pubmed-meshheading:16166454-RNA, Small Interfering,
pubmed-meshheading:16166454-RNA Interference,
pubmed-meshheading:16166454-Tetradecanoylphorbol Acetate,
pubmed-meshheading:16166454-Transfection,
pubmed-meshheading:16166454-Uterine Cervical Neoplasms
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Enhancement of cisplatin sensitivity of cisplatin-resistant human cervical carcinoma cells by bryostatin 1.
|
|
pubmed:affiliation |
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
|
