Linked Life Data

16166344

Source:http://linkedlifedata.com/resource/pubmed/id/16166344

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-12
pubmed:abstractText
Premature infants receiving chronic total parenteral nutrition (TPN) due to feeding intolerance develop intestinal atrophy and reduced nutrient absorption. Although providing the intestinal trophic hormone glucagon-like peptide-2 (GLP-2) during chronic TPN improves intestinal growth and morphology, it is uncertain whether GLP-2 enhances absorptive function. We placed catheters in the carotid artery, jugular and portal veins, duodenum, and a portal vein flow probe in piglets before providing either enteral formula (ENT), TPN or a coinfusion of TPN plus GLP-2 for 6 days. On postoperative day 7, all piglets were fed enterally and digestive functions were evaluated in vivo using dual infusion of enteral ((13)C) and intravenous ((2)H) glucose, in vitro by measuring mucosal lactase activity and rates of apical glucose transport, and by assessing the abundances of sodium glucose transporter-1 (SGLT-1) and glucose transporter-2 (GLUT2). Both ENT and GLP-2 pigs had larger intestine weights, longer villi, and higher lactose digestive capacity and in vivo net glucose and galactose absorption compared with TPN alone. These endpoints were similar in ENT and GLP-2 pigs except for a lower intestinal weight and net glucose absorption in GLP-2 compared with ENT pigs. The enhanced hexose absorption in GLP-2 compared with TPN pigs corresponded with higher lactose digestive and apical glucose transport capacities, increased abundance of SGLT-1, but not GLUT-2, and lower intestinal metabolism of [(13)C]glucose to [(13)C]lactate. Our findings indicate that GLP-2 treatment during chronic TPN maintains intestinal structure and lactose digestive and hexose absorptive capacities, reduces intestinal hexose metabolism, and may facilitate the transition to enteral feeding in TPN-fed infants.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0193-1857
pubmed:author
pubmed:issnType
Print
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G293-300
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:16166344-Algorithms, pubmed-meshheading:16166344-Animals, pubmed-meshheading:16166344-Animals, Newborn, pubmed-meshheading:16166344-Carbon Dioxide, pubmed-meshheading:16166344-DNA, pubmed-meshheading:16166344-Glucagon-Like Peptide 2, pubmed-meshheading:16166344-Glucagon-Like Peptides, pubmed-meshheading:16166344-Glucose, pubmed-meshheading:16166344-Glucose Transporter Type 2, pubmed-meshheading:16166344-Hexoses, pubmed-meshheading:16166344-Ileum, pubmed-meshheading:16166344-Infusions, Intravenous, pubmed-meshheading:16166344-Jejunum, pubmed-meshheading:16166344-Kinetics, pubmed-meshheading:16166344-Lactase, pubmed-meshheading:16166344-Malabsorption Syndromes, pubmed-meshheading:16166344-Oxygen Consumption, pubmed-meshheading:16166344-Parenteral Nutrition, Total, pubmed-meshheading:16166344-Sodium-Glucose Transporter 1, pubmed-meshheading:16166344-Swine, pubmed-meshheading:16166344-Tissue Distribution
pubmed:year
2006
pubmed:articleTitle
Glucagon-like peptide-2 protects against TPN-induced intestinal hexose malabsorption in enterally refed piglets.
pubmed:affiliation
USDA-ARS, Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural