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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
39
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pubmed:dateCreated |
2005-9-28
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pubmed:abstractText |
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-12393483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-12434020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-14563119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-14573789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-14634621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-14695998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-14744438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-14973191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15172979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15210942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15284443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15502875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15503311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15652477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15685193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15728813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15738415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15766527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15806104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15867338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15944707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-15944709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-16009126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-2106002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-3874430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-6093263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-8653779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16166262-9558396
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
pubmed-author:AlderHansjuergH,
pubmed-author:AqeilanRami IRI,
pubmed-author:CalinGeorge AdrianGA,
pubmed-author:CimminoAmeliaA,
pubmed-author:CroceCarlo MCM,
pubmed-author:DonoMariellaM,
pubmed-author:FabbriMullerM,
pubmed-author:FerracinManuelaM,
pubmed-author:IorioMarilena VMV,
pubmed-author:KippsThomas JTJ,
pubmed-author:LiuChang-GongCG,
pubmed-author:NegriniMassimoM,
pubmed-author:RassentiLauraL,
pubmed-author:ShimizuMasayoshiM,
pubmed-author:VoliniaStefanoS,
pubmed-author:WojcikSylwia ESE,
pubmed-author:ZupoSimonaS
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13944-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16166262-Apoptosis,
pubmed-meshheading:16166262-Cell Proliferation,
pubmed-meshheading:16166262-Gene Expression Regulation, Leukemic,
pubmed-meshheading:16166262-Humans,
pubmed-meshheading:16166262-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16166262-MicroRNAs,
pubmed-meshheading:16166262-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:16166262-Transcription, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
miR-15 and miR-16 induce apoptosis by targeting BCL2.
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pubmed:affiliation |
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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