| pubmed-article:16166201 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16166201 | lifeskim:mentions | umls-concept:C1720997 | lld:lifeskim |
| pubmed-article:16166201 | lifeskim:mentions | umls-concept:C0013470 | lld:lifeskim |
| pubmed-article:16166201 | lifeskim:mentions | umls-concept:C0052181 | lld:lifeskim |
| pubmed-article:16166201 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:16166201 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16166201 | pubmed:dateCreated | 2005-12-14 | lld:pubmed |
| pubmed-article:16166201 | pubmed:abstractText | Apolipoprotein (apo) A-IV is an anorexigenic gastrointestinal peptide that is also synthesized in the hypothalamus. The goal of these experiments was to determine whether apo A-IV interacts with the central melanocortin (MC) system in the control of feeding. The third ventricular (i3vt) administration of a subthreshold dose of apo A-IV (0.5 microg) potentiated i3vt MC-induced (metallothionein-II, 0.03 nmol) suppression of 30-min feeding in Long-Evans rats. A subthreshold dose of the MC antagonist (SHU9119, 0.1 nmol, i3vt) completely attenuated the anorectic effect of i3vt apo A-IV (1.5 microg). The i3vt apo A-IV significantly elevated the expression of c-Fos in neurons of the paraventricular nucleus of the hypothalamus, but not in the arcuate nucleus or median eminence. In addition, c-Fos expression was not colocalized with proopiomelanocortin-positive neurons. These data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate. | lld:pubmed |
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| pubmed-article:16166201 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16166201 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16166201 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16166201 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16166201 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16166201 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16166201 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:TsoPatrickP | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:DavidsonW... | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:LiuMinM | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:BenoitStephen... | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:WoodsStephen... | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:SeeleyRandy... | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:CleggDeborah... | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:D'AlessioDavi... | lld:pubmed |
| pubmed-article:16166201 | pubmed:author | pubmed-author:GotohKoroK | lld:pubmed |
| pubmed-article:16166201 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16166201 | pubmed:volume | 290 | lld:pubmed |
| pubmed-article:16166201 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16166201 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16166201 | pubmed:pagination | R202-7 | lld:pubmed |
| pubmed-article:16166201 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16166201 | pubmed:meshHeading | pubmed-meshheading:16166201... | lld:pubmed |
| pubmed-article:16166201 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16166201 | pubmed:articleTitle | Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. | lld:pubmed |
| pubmed-article:16166201 | pubmed:affiliation | Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA. | lld:pubmed |
| pubmed-article:16166201 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16166201 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:25080 | entrezgene:pubmed | pubmed-article:16166201 | lld:entrezgene |
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