16165109

Source:http://linkedlifedata.com/resource/pubmed/id/16165109

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018801, umls-concept:C0026336, umls-concept:C0034693, umls-concept:C0034721, umls-concept:C0038952, umls-concept:C0085542, umls-concept:C0442805, umls-concept:C0623362, umls-concept:C1150224, umls-concept:C1522564
pubmed:issue	3
pubmed:dateCreated	2006-1-30
pubmed:abstractText	Oxidative stress is implicated in the pathogenesis of heart failure and affects the activity of matrix metalloproteinases (MMPs). We have now investigated the role of MMPs and their tissue inhibitors (TIMPs) in the transition from compensated left ventricular (LV) hypertrophy to heart failure as well as the effects of pravastatin on this transition in a rat model.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0077427
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Atrial Natriuretic Factor, http://linkedlifedata.com/resource/pubmed/chemical/Collagen, http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases, http://linkedlifedata.com/resource/pubmed/chemical/Myosin Heavy Chains, http://linkedlifedata.com/resource/pubmed/chemical/NADPH Oxidase, http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, Brain, http://linkedlifedata.com/resource/pubmed/chemical/Pravastatin, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/Sodium Chloride, Dietary, http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of..., http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0008-6363
pubmed:author	pubmed-author:IchiharaGakuG, pubmed-author:IchiharaSahokoS, pubmed-author:KawanishiShosukeS, pubmed-author:NagataKohzoK, pubmed-author:NodaAkikoA, pubmed-author:ObataKojiK, pubmed-author:OikawaShinjiS, pubmed-author:XuJinglanJ, pubmed-author:YamadaYoshijiY, pubmed-author:YokotaMitsuhiroM
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	69
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	726-35
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:16165109-Animals, pubmed-meshheading:16165109-Anticholesteremic Agents, pubmed-meshheading:16165109-Atrial Natriuretic Factor, pubmed-meshheading:16165109-Collagen, pubmed-meshheading:16165109-Disease Progression, pubmed-meshheading:16165109-Fibronectins, pubmed-meshheading:16165109-Glutathione, pubmed-meshheading:16165109-Heart Failure, pubmed-meshheading:16165109-Hypertrophy, Left Ventricular, pubmed-meshheading:16165109-Male, pubmed-meshheading:16165109-Matrix Metalloproteinase 2, pubmed-meshheading:16165109-Matrix Metalloproteinase 9, pubmed-meshheading:16165109-Matrix Metalloproteinases, pubmed-meshheading:16165109-Models, Animal, pubmed-meshheading:16165109-Myocardium, pubmed-meshheading:16165109-Myosin Heavy Chains, pubmed-meshheading:16165109-NADPH Oxidase, pubmed-meshheading:16165109-Natriuretic Peptide, Brain, pubmed-meshheading:16165109-Oxidative Stress, pubmed-meshheading:16165109-Pravastatin, pubmed-meshheading:16165109-RNA, Messenger, pubmed-meshheading:16165109-Rats, pubmed-meshheading:16165109-Rats, Inbred Dahl, pubmed-meshheading:16165109-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16165109-Sodium Chloride, Dietary, pubmed-meshheading:16165109-Tissue Inhibitor of Metalloproteinase-1, pubmed-meshheading:16165109-Tissue Inhibitor of Metalloproteinase-2
pubmed:year	2006
pubmed:articleTitle	Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.
pubmed:affiliation	Department of Cardiovascular Genome Science, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
pubmed:publicationType	Journal Article