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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-9-16
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pubmed:abstractText |
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, characterized by mesangial IgA1 deposits. We have previously demonstrated that IgAN patients have a hampered IgA immune response after mucosal challenge with a neoantigen. Dendritic cells are critically involved in the initiation of humoral immune responses, not only via activation of T-helper cells, but also via direct effect on naïve B cells. The aim of this study was to investigate the capacity of dendritic cells from IgAN patients to regulate IgA production.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1604-12
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pubmed:meshHeading |
pubmed-meshheading:16164637-Adult,
pubmed-meshheading:16164637-B-Lymphocytes,
pubmed-meshheading:16164637-CD40 Ligand,
pubmed-meshheading:16164637-Cell Communication,
pubmed-meshheading:16164637-Cells, Cultured,
pubmed-meshheading:16164637-Coculture Techniques,
pubmed-meshheading:16164637-Culture Media, Conditioned,
pubmed-meshheading:16164637-Dendritic Cells,
pubmed-meshheading:16164637-Female,
pubmed-meshheading:16164637-Glomerulonephritis, IGA,
pubmed-meshheading:16164637-Humans,
pubmed-meshheading:16164637-Immunoglobulin A,
pubmed-meshheading:16164637-Immunoglobulin G,
pubmed-meshheading:16164637-Immunoglobulin M,
pubmed-meshheading:16164637-Immunophenotyping,
pubmed-meshheading:16164637-Male,
pubmed-meshheading:16164637-Middle Aged
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pubmed:year |
2005
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pubmed:articleTitle |
Dendritic cells of IgA nephropathy patients have an impaired capacity to induce IgA production in naïve B cells.
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pubmed:affiliation |
Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article
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