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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-9-16
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pubmed:abstractText |
Apoptotic death of renal proximal tubular epithelial cells (RPTECs) is a feature of acute and chronic renal failure. RPTECs are directly damaged by ischemia, inflammatory, and cytotoxic mediators but also contribute to their own demise by up-regulating proinflammatory nuclear factor-kappaB (NF-kappaB)-dependent proteins. In endothelial cells, the Bcl family member A1 and the zinc finger protein A20 have redundant and dual antiapoptotic and anti-inflammatory effects. We studied the function(s) of A1 and A20 in human RPTECs in vitro.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/BCL2-related protein A1,
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/TNFAIP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0085-2538
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pubmed:author |
pubmed-author:ArveloMaria BMB,
pubmed-author:ChoiJeanJ,
pubmed-author:CzismadiaEvaE,
pubmed-author:DanielSoizicS,
pubmed-author:FerranChristianeC,
pubmed-author:FloegeJürgenJ,
pubmed-author:GreyShane TST,
pubmed-author:KunterUtaU,
pubmed-author:LongoChristopher RCR,
pubmed-author:MottleyChristinaC,
pubmed-author:PatelVirendra IVI,
pubmed-author:RochaEduardoE,
pubmed-author:ScaliSalvatore TST,
pubmed-author:ShrikhandeGautamG,
pubmed-author:ShukriTalaT
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1520-32
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pubmed:dateRevised |
2008-1-9
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pubmed:meshHeading |
pubmed-meshheading:16164629-Antigens, CD95,
pubmed-meshheading:16164629-Apoptosis,
pubmed-meshheading:16164629-Cells, Cultured,
pubmed-meshheading:16164629-Chemokine CCL2,
pubmed-meshheading:16164629-Epithelial Cells,
pubmed-meshheading:16164629-Gene Expression,
pubmed-meshheading:16164629-Humans,
pubmed-meshheading:16164629-I-kappa B Proteins,
pubmed-meshheading:16164629-Intercellular Adhesion Molecule-1,
pubmed-meshheading:16164629-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:16164629-Kidney Tubules, Proximal,
pubmed-meshheading:16164629-NF-kappa B,
pubmed-meshheading:16164629-Nephritis,
pubmed-meshheading:16164629-Nuclear Proteins,
pubmed-meshheading:16164629-Proteins,
pubmed-meshheading:16164629-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:16164629-RNA, Messenger,
pubmed-meshheading:16164629-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16164629-Up-Regulation
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pubmed:year |
2005
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pubmed:articleTitle |
Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells.
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pubmed:affiliation |
Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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