rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-9-15
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pubmed:abstractText |
Signal transduction involving the activation of phospholipase A2 (PLA2) to release arachidonic acid (AA) from membrane phospholipids, when coupled to dopamine D1- and D2-type receptors, can be imaged in rats having a chronic unilateral lesion of the substantia nigra. It is not known, however, if the signaling responses occur in the absence of a lesion. To determine this, we used our in vivo fatty acid method to measure signaling in response to D1 and D2 receptor agonists given acutely to unanesthetized rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-p...,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Isotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Quinpirole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
735-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16163535-2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine,
pubmed-meshheading:16163535-Animals,
pubmed-meshheading:16163535-Arachidonic Acid,
pubmed-meshheading:16163535-Autoradiography,
pubmed-meshheading:16163535-Brain,
pubmed-meshheading:16163535-Carbon Isotopes,
pubmed-meshheading:16163535-Dopamine Agonists,
pubmed-meshheading:16163535-Drug Administration Routes,
pubmed-meshheading:16163535-Drug Interactions,
pubmed-meshheading:16163535-Male,
pubmed-meshheading:16163535-Quinpirole,
pubmed-meshheading:16163535-Rats,
pubmed-meshheading:16163535-Rats, Inbred F344,
pubmed-meshheading:16163535-Receptors, Dopamine D1,
pubmed-meshheading:16163535-Receptors, Dopamine D2,
pubmed-meshheading:16163535-Signal Transduction,
pubmed-meshheading:16163535-Wakefulness
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pubmed:year |
2005
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pubmed:articleTitle |
D2 but not D1 dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized rats.
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pubmed:affiliation |
Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg. 9, Room 1S128, Bethesda, MD 20892, USA. abeshb@mail.nih.gov
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pubmed:publicationType |
Journal Article,
Comparative Study
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