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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-9-15
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pubmed:abstractText |
Kinetic studies of photoreceptor cell death in the retinal degeneration (rd1) mouse model suggest that photoreceptor degeneration could result from cumulative damage. Since alterations in glutamate metabolism have been described in different models of retinitis pigmentosa, we investigated in the present work whether changes in glutamate turnover occur in the degenerating rd1 retina and whether glutamate-mediated excitotoxic mechanisms may contribute to rod photoreceptor death in this model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate-Ammonia Ligase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Slc1a3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Vimentin
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-0535
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
688-96
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16163266-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:16163266-Amino Acids,
pubmed-meshheading:16163266-Animals,
pubmed-meshheading:16163266-Blotting, Western,
pubmed-meshheading:16163266-Cell Survival,
pubmed-meshheading:16163266-Chromatography, Ion Exchange,
pubmed-meshheading:16163266-Electroretinography,
pubmed-meshheading:16163266-Excitatory Amino Acid Antagonists,
pubmed-meshheading:16163266-Excitatory Amino Acid Transporter 1,
pubmed-meshheading:16163266-Glutamate-Ammonia Ligase,
pubmed-meshheading:16163266-Glutamic Acid,
pubmed-meshheading:16163266-Glutamine,
pubmed-meshheading:16163266-Injections, Intraperitoneal,
pubmed-meshheading:16163266-Mice,
pubmed-meshheading:16163266-Mice, Inbred C3H,
pubmed-meshheading:16163266-Mice, Inbred C57BL,
pubmed-meshheading:16163266-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:16163266-RNA, Messenger,
pubmed-meshheading:16163266-Retinal Degeneration,
pubmed-meshheading:16163266-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16163266-Up-Regulation,
pubmed-meshheading:16163266-Vimentin
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pubmed:year |
2005
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pubmed:articleTitle |
Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina.
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pubmed:affiliation |
Laboratoire de Physiopathologie Cellulaire et Moléculaire de la Rétine, Institut National de la Santé et de la Recherche Médicale (Inserm U592), Université Pierre et Marie Curie, Paris, France. marie-noelle.delyfer@libertysurf.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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