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pubmed:abstractText |
Steatosis may increase oxidative stress, which is counteracted by cellular enzymatic (cytosolic and mitochondrial superoxide dismutases (Cu/Zn-SOD and Mn-SOD), glutathione peroxidase (GPx), catalase) and non-enzymatic antioxidant systems. We aimed to determine, in patients with non-alcoholic fatty liver disease (NAFLD), the level of antioxidant defenses (1) in liver biopsies, to demonstrate the existence of oxidative stress; (2) in erythrocytes and plasma, to determine whether their antioxidant defenses reflect liver oxidative stress.
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pubmed:affiliation |
Service d'hépato-gastroentérologie, Hôpital Antoine Béclère, AP-HP, 157 rue de la Porte de Trivaux, 92141 Clamart Cedex, France. gabriel.perlemuter@abc.aphp.fr
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