Linked Life Data

16161349

Source:http://linkedlifedata.com/resource/pubmed/id/16161349

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-9-15
pubmed:abstractText
The phenomenon of multidrug resistance is connected with an increased efflux of cytotoxic agents from the cells and is a serious problem in the treatment with anthracycline antibiotics. Search for new antitumor drugs from the anthracycline group are focused on the syntheris of derivatives with changes in saccharide and anthracycline parts. The genotoxic activity of selected nine new derivatives of anthracycline was evaluate basing on reference tests: micronucleus test in vitro and the Ames test. A correlation was observed between the results obtained in the Ames test and those received in the micronucleus test. In both tests, derivative WP903 demonstrated a strong genotoxic action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-104
pubmed:meshHeading
pubmed:articleTitle
Evaluation of mutagenic and genotoxic activities of new derivatives of anthracyclines.
pubmed:affiliation
Department of Biochemistry and Biopharmaceuticals, National Institute of Public Health, 30/34 Che?mnska Str., 00-725 Warsaw, Poland.
pubmed:publicationType
Journal Article