| pubmed-article:1616052 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C0038891 | lld:lifeskim |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C0031586 | lld:lifeskim |
| pubmed-article:1616052 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1616052 | pubmed:issue | 6 Pt 1 | lld:pubmed |
| pubmed-article:1616052 | pubmed:dateCreated | 1992-7-29 | lld:pubmed |
| pubmed-article:1616052 | pubmed:abstractText | Tumor necrosis factor-alpha (TNF-alpha) and the phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) decrease the synthesis of surfactant proteins association with decreased SP-A and SP-B mRNA. Nuclear run-on assays were utilized to test whether the inhibitory effects of TNF-alpha and TPA were associated with changes in surfactant protein gene transcription. SP-A gene transcription was inhibited by both TNF-alpha and TPA as assessed by nuclear run-on assays. Inhibitory effects of both agents on SP-A gene transcription were readily detected within 6 h after exposure and persisted for 24 h. While TNF-alpha and TPA decreased cellular SP-B mRNA content, transcription of the SP-B gene was not influenced by these agents. In contrast to the inhibitory effects of TPA and TNF-alpha on SP-A and SP-B mRNAs, steady-state mRNA and rate of transcription of human manganese superoxide dismutase (MnSOD) were increased by both agents. The time course and extent of increased MnSOD gene transcription by TNF-alpha and TPA were distinct. Transcription of the human beta-actin gene was not altered by either agent. The inhibitory effects of TPA and TNF-alpha on SP-A expression in pulmonary adenocarcinoma cells are associated with the inhibition of SP-A gene transcription. Loss of SP-B mRNA was not accompanied by decreased SP-B gene transcription. Actinomycin D blocked the inhibitory effects of TNF-alpha and TPA on SP-A and SP-B mRNA, supporting a role for posttranscriptional events in the modulation of the expression of the surfactant proteins SP-A and SP-B. | lld:pubmed |
| pubmed-article:1616052 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1616052 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1616052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1616052 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1616052 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1616052 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1616052 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:1616052 | pubmed:author | pubmed-author:ClarkJ CJC | lld:pubmed |
| pubmed-article:1616052 | pubmed:author | pubmed-author:WhitsettJ AJA | lld:pubmed |
| pubmed-article:1616052 | pubmed:author | pubmed-author:WispéJ RJR | lld:pubmed |
| pubmed-article:1616052 | pubmed:author | pubmed-author:PryhuberG SGS | lld:pubmed |
| pubmed-article:1616052 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1616052 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:1616052 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1616052 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1616052 | pubmed:pagination | L688-93 | lld:pubmed |
| pubmed-article:1616052 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1616052 | pubmed:meshHeading | pubmed-meshheading:1616052-... | lld:pubmed |
| pubmed-article:1616052 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1616052 | pubmed:articleTitle | Effects of TNF-alpha and phorbol ester on human surfactant protein and MnSOD gene transcription in vitro. | lld:pubmed |
| pubmed-article:1616052 | pubmed:affiliation | Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229. | lld:pubmed |
| pubmed-article:1616052 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1616052 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1616052 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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