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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-23
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pubmed:abstractText |
Graft-versus-host disease (GVHD) is a multistep disease process following allogeneic bone marrow transplantation (BMT). It has been postulated that the induction of acute GVHD requires the presence of Peyer patches (PPs). A new tumor necrosis factor (TNF)-deficient strain has been developed that totally lacks PPs and displays the defects characteristic of TNF ablation but not lymphotoxin-associated defects characterized by lack of both PPs and lymph nodes. To determine the necessity of PPs in acute lethal GVHD induction, we transplanted full major histocompatibility complex (MHC)-mismatched grafts into myeloablated TNF knockout recipients. No differences in the survival or GVHD-associated histopathologic lesions were observed between the recipients. We conclude that neither PPs nor host TNF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-10725718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-11267498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-12424195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-12524535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-14563643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-15003318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-1522226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-15240671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-15664162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-15832287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-3486193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-8171322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-8513499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-8691140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-8879212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-9177215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-9223320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-9368616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16160014-9565643
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
410-2
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16160014-Acute Disease,
pubmed-meshheading:16160014-Animals,
pubmed-meshheading:16160014-Bone Marrow Transplantation,
pubmed-meshheading:16160014-Graft vs Host Disease,
pubmed-meshheading:16160014-Intestinal Diseases,
pubmed-meshheading:16160014-Mice,
pubmed-meshheading:16160014-Mice, Knockout,
pubmed-meshheading:16160014-Peyer's Patches,
pubmed-meshheading:16160014-Transplantation, Homologous,
pubmed-meshheading:16160014-Transplantation Conditioning,
pubmed-meshheading:16160014-Tumor Necrosis Factor-alpha
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pubmed:year |
2006
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pubmed:articleTitle |
Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation.
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pubmed:affiliation |
Department of Microbiology and Immunology, University of Nevada School of Medicine, Mail Stop 199, Reno, NV 89557, USA. lwelniak@unr.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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