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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-6
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pubmed:abstractText |
Polycystic ovary syndrome (PCOS) theca cells secrete increased levels of androgens. The mRNA and protein levels of the transcription factor GATA6, which regulates expression of several steroidogenic enzymes, are increased in PCOS theca cells. Thus, GATA6 is a PCOS candidate gene.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-972X
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pubmed:author |
pubmed-author:AnkenerWendyW,
pubmed-author:DunaifAndreaA,
pubmed-author:EwensKathrynK,
pubmed-author:HoClement K MCK,
pubmed-author:LegroRichard SRS,
pubmed-author:McAllisterJan MJM,
pubmed-author:Nelson-DegraveVelenV,
pubmed-author:SpielmanRichardR,
pubmed-author:StewartDouglas RDR,
pubmed-author:StraussJerome FJF3rd,
pubmed-author:WickenheisserJessicaJ,
pubmed-author:WoodJennifer RJR,
pubmed-author:ZhangZhibingZ
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pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6596-602
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16159937-Base Sequence,
pubmed-meshheading:16159937-Cells, Cultured,
pubmed-meshheading:16159937-DNA, Recombinant,
pubmed-meshheading:16159937-Female,
pubmed-meshheading:16159937-GATA6 Transcription Factor,
pubmed-meshheading:16159937-Genetic Variation,
pubmed-meshheading:16159937-Humans,
pubmed-meshheading:16159937-Molecular Sequence Data,
pubmed-meshheading:16159937-Polycystic Ovary Syndrome,
pubmed-meshheading:16159937-Polymerase Chain Reaction,
pubmed-meshheading:16159937-Protein Isoforms,
pubmed-meshheading:16159937-RNA, Messenger,
pubmed-meshheading:16159937-RNA Stability,
pubmed-meshheading:16159937-Theca Cells,
pubmed-meshheading:16159937-Transcription, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Increased transcription and increased messenger ribonucleic acid (mRNA) stability contribute to increased GATA6 mRNA abundance in polycystic ovary syndrome theca cells.
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pubmed:affiliation |
Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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