|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
21
|
|
pubmed:dateCreated |
2005-10-24
|
|
pubmed:abstractText |
Mass spectrometric profiles of peptides and proteins obtained by current technologies are characterized by complex spectra, high dimensionality and substantial noise. These characteristics generate challenges in the discovery of proteins and protein-profiles that distinguish disease states, e.g. cancer patients from healthy individuals. We present low-level methods for the processing of mass spectral data and a machine learning method that combines support vector machines, with particle swarm optimization for biomarker selection.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1367-4803
|
|
pubmed:author |
pubmed-author:Abdel-HamidMohamedM,
pubmed-author:ConradsThomas PTP,
pubmed-author:EissaSohair Abdel-LatifSA,
pubmed-author:GoldmanLenkaL,
pubmed-author:GoldmanRadoslavR,
pubmed-author:LoffredoChristopher ACA,
pubmed-author:PetricoinEmanuel FEF,
pubmed-author:RessomHabtom WHW,
pubmed-author:SahaDanielD,
pubmed-author:VargheseRency SRS,
pubmed-author:VeenstraTimothy DTD
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
21
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4039-45
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16159919-Algorithms,
pubmed-meshheading:16159919-Artificial Intelligence,
pubmed-meshheading:16159919-Blood Chemical Analysis,
pubmed-meshheading:16159919-Diagnosis, Computer-Assisted,
pubmed-meshheading:16159919-Gene Expression Profiling,
pubmed-meshheading:16159919-Humans,
pubmed-meshheading:16159919-Liver Neoplasms,
pubmed-meshheading:16159919-Neoplasm Proteins,
pubmed-meshheading:16159919-Peptide Mapping,
pubmed-meshheading:16159919-Reproducibility of Results,
pubmed-meshheading:16159919-Sensitivity and Specificity,
pubmed-meshheading:16159919-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:16159919-Tumor Markers, Biological
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Analysis of mass spectral serum profiles for biomarker selection.
|
|
pubmed:affiliation |
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. hwr@georgetown.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
