Source:http://linkedlifedata.com/resource/pubmed/id/16158962
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3B
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| pubmed:dateCreated |
2005-9-14
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| pubmed:abstractText |
The aim of this study was to investigate pRb2/p130, p107 and p53 expressions in precancerous lesions and squamous cell carcinoma (SCC) of the uterine cervix. We evaluated Human Papillomavirus (HPV) testing and typing and pRb2/p130, p107 and p53 expressions (antibody D07) of 48 patients showing low-grade cervical intraepithelial neoplasia (LCIN, 18 cases), high-grade CIN (HCIN, 13 cases) and SCC (17 cases). Paraffin-embedded tissue sections were analyzed for the study. High-risk HPV types were present in 67%, 89% and in 100% of HPV-positive LCIN, HCIN and SCC, respectively (Spearman's correlation coefficient: 0.393, p=0.035). Positive pRb2/p130 expression was detected in 89% of LCIN, 77% of HCIN and in 35% of SCC (p=0.001), whereas diffuse p107 expression was 72%, 62% and 100%, respectively (p=0.024). The results of p53 expression in CINs and SCCs showed values (not statistically significant) comparable with the literature data concerning the antibody D07. For the first time, we tested pRb2/p130 and p107 expressions in CINs and SCCs. We found a progressive decrease in pRb2 expression from CINs to SCCs that suggests an important role of pRb2 in cervical carcinogenesis. Indeed, p107 expression does not seem to be a useful factor. In our opinion, confirmed by the literature data, p53 immunostaining helps to biologically characterize CIN (in particular LCIN) when each case is evaluated separately considering HPV testing/typing.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RBL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Like Protein p107,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Like Protein p130,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0250-7005
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
25
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2187-92
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16158962-Adult,
pubmed-meshheading:16158962-Carcinoma, Squamous Cell,
pubmed-meshheading:16158962-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:16158962-Female,
pubmed-meshheading:16158962-Humans,
pubmed-meshheading:16158962-Immunohistochemistry,
pubmed-meshheading:16158962-Middle Aged,
pubmed-meshheading:16158962-Nuclear Proteins,
pubmed-meshheading:16158962-Papillomaviridae,
pubmed-meshheading:16158962-Papillomavirus Infections,
pubmed-meshheading:16158962-Precancerous Conditions,
pubmed-meshheading:16158962-Proteins,
pubmed-meshheading:16158962-Retinoblastoma Protein,
pubmed-meshheading:16158962-Retinoblastoma-Like Protein p107,
pubmed-meshheading:16158962-Retinoblastoma-Like Protein p130,
pubmed-meshheading:16158962-Tumor Suppressor Protein p53,
pubmed-meshheading:16158962-Uterine Cervical Neoplasms
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| pubmed:articleTitle |
PRb2/p130, p107 and p53 expression in precancerous lesions and squamous cell carcinoma of the uterine cervix.
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| pubmed:affiliation |
Department of Experimental Medicine and Pathology, "La Sapienza" University, Rome, Italy.
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| pubmed:publicationType |
Journal Article
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