|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2005-9-13
|
|
pubmed:abstractText |
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
1526-632X
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
13
|
|
pubmed:volume |
65
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
745-7
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:16157910-Adult,
pubmed-meshheading:16157910-Atrophy,
pubmed-meshheading:16157910-Brain Mapping,
pubmed-meshheading:16157910-Cerebral Cortex,
pubmed-meshheading:16157910-Cognition Disorders,
pubmed-meshheading:16157910-Corpus Striatum,
pubmed-meshheading:16157910-DNA Mutational Analysis,
pubmed-meshheading:16157910-Female,
pubmed-meshheading:16157910-Genetic Testing,
pubmed-meshheading:16157910-Genotype,
pubmed-meshheading:16157910-Humans,
pubmed-meshheading:16157910-Huntington Disease,
pubmed-meshheading:16157910-Magnetic Resonance Imaging,
pubmed-meshheading:16157910-Male,
pubmed-meshheading:16157910-Middle Aged,
pubmed-meshheading:16157910-Nerve Tissue Proteins,
pubmed-meshheading:16157910-Neuropsychological Tests,
pubmed-meshheading:16157910-Nuclear Proteins,
pubmed-meshheading:16157910-Trinucleotide Repeats
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.
|
|
pubmed:affiliation |
Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. rosas@helix.mgh.harvard.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
