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rdf:type |
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lifeskim:mentions |
umls-concept:C0017837,
umls-concept:C0392514,
umls-concept:C0449258,
umls-concept:C0681842,
umls-concept:C0681850,
umls-concept:C1550501,
umls-concept:C1623038,
umls-concept:C1706203,
umls-concept:C1882417,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
16
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pubmed:dateCreated |
2005-9-13
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pubmed:abstractText |
Oxidative stress plays an important pathogenic role in hereditary hemochromatosis (HHC) and chronic hepatitis C virus infection (CHC). Several enzymes involved in the degradation of reactive oxidants and xenobiotics, such as glutathione S-transferase P1 (GSTP1) and manganese superoxide dismutase (MnSOD), reveal polymorphisms that affect their antioxidant capacity and may therefore modulate the progression to cirrhosis. Our objective was to establish the role of the functional polymorphisms of GSTP1 (codon 105 Ile-->Val) and MnSOD (codon 16 of precursor protein Ala-->Val) on the evolution of cirrhosis in patients with HHC and CHC.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0003-9926
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1835-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16157826-Adult,
pubmed-meshheading:16157826-Aged,
pubmed-meshheading:16157826-Aged, 80 and over,
pubmed-meshheading:16157826-Alanine,
pubmed-meshheading:16157826-Disease Progression,
pubmed-meshheading:16157826-Female,
pubmed-meshheading:16157826-Genotype,
pubmed-meshheading:16157826-Glutathione Transferase,
pubmed-meshheading:16157826-Hemochromatosis,
pubmed-meshheading:16157826-Hepatitis C, Chronic,
pubmed-meshheading:16157826-Humans,
pubmed-meshheading:16157826-Isoleucine,
pubmed-meshheading:16157826-Liver Cirrhosis,
pubmed-meshheading:16157826-Logistic Models,
pubmed-meshheading:16157826-Male,
pubmed-meshheading:16157826-Middle Aged,
pubmed-meshheading:16157826-Oxidative Stress,
pubmed-meshheading:16157826-Polymorphism, Genetic,
pubmed-meshheading:16157826-Prognosis,
pubmed-meshheading:16157826-Valine
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pubmed:year |
2005
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pubmed:articleTitle |
Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis.
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pubmed:affiliation |
Department of Medicine I, University of Erlangen-Nürnberg, Erlangen, Germany. felix.stickel@med1.imed.uni-erlangen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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