|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-9-13
|
|
pubmed:abstractText |
Endothelial cells in tumor angiogenesis are highly accessible, genetically stable and present unique molecular markers for targeted therapy. Neoplasia is also characterized by enhanced vascular permeability and disordered lymphatics so that both active and passive targeting strategies may play a role in localizing angiogenesis-targeted agents. To investigate the relative importance of these targeting strategies, the tissue biodistribution of both endothelial-specific and nonspecific peptides and their macromolecular peptide-copolymer conjugates were studied in 2 xenograft models of prostate cancer. Tumor-to-normal tissue background ratios (T/B) of these constructs were compared to evaluate the effect of molecular size on blood clearance and nonspecific vascular permeability.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0161-5505
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
46
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1552-60
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:16157540-Animals,
pubmed-meshheading:16157540-Cell Line, Tumor,
pubmed-meshheading:16157540-Drug Delivery Systems,
pubmed-meshheading:16157540-Humans,
pubmed-meshheading:16157540-Integrin alphaVbeta3,
pubmed-meshheading:16157540-Male,
pubmed-meshheading:16157540-Metabolic Clearance Rate,
pubmed-meshheading:16157540-Methacrylates,
pubmed-meshheading:16157540-Mice,
pubmed-meshheading:16157540-Mice, SCID,
pubmed-meshheading:16157540-Neovascularization, Pathologic,
pubmed-meshheading:16157540-Oligopeptides,
pubmed-meshheading:16157540-Organ Specificity,
pubmed-meshheading:16157540-Prostatic Neoplasms,
pubmed-meshheading:16157540-Tissue Distribution
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Targeting tumor angiogenesis: comparison of peptide and polymer-peptide conjugates.
|
|
pubmed:affiliation |
Division of Nuclear Medicine, Department of Radiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. bline@umm.edu
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
|
